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The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two-Kidney One-Clip Hypertensive Rats
Joint Authors
Aisa, Rayile
Yu, Zhaoxia
Zhang, Xiangyang
Maimaitiyiming, Dilinuer
Huang, Lipeng
Hasim, Ayshamgul
Jiang, Tao
Duan, Mingjun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aims.
The aim of this study was to investigate the effects of the aqueous extract of Nardostachys chinensis Batalin (NCBAE) on blood pressure and cardiac hypertrophy using two-kidney one-clip (2K1C) hypertensive rats.
Methods.
2K1C rat models were set up by clipping the left renal artery.
Sham-operated rats underwent the same surgical procedure except for renal arterial clipping.
2K1C hypertensive rats were orally given NCBAE at doses of 210, 420, and 630 mg·kg−1·d−1 for 6 weeks.
Twelve weeks after surgery, rat SBP and echocardiographic parameters were measured, cardiac histopathology was assessed, serum NO and LDH were detected, and the expression of Bcl-2 and caspase-3 of left ventricular tissue was assessed by western blot.
Results.
Treatment with NCBAE resulted in a decrease of SBP, LVPWd, LVPWs, IVSd, IVSs, LVW/BW ratio, and cardiomyocyte CSA, an increase of LVEF, and inhibition of 2K1C-induced reduction in serum NO and elevation of LDH compared with 2K1C group.
NCBAE intervention also showed a significant increase of Bcl-2 expression and reduction of cleaved caspase-3 level dose-dependently in left ventricular tissue.
Conclusion.
Our data demonstrate that NCBAE has an antihypertensive property and protective effect on 2K1C-induced cardiac hypertrophy especially at the dose of 630 mg·kg−1·d−1.
American Psychological Association (APA)
Aisa, Rayile& Yu, Zhaoxia& Zhang, Xiangyang& Maimaitiyiming, Dilinuer& Huang, Lipeng& Hasim, Ayshamgul…[et al.]. 2017. The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two-Kidney One-Clip Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153630
Modern Language Association (MLA)
Aisa, Rayile…[et al.]. The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two-Kidney One-Clip Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153630
American Medical Association (AMA)
Aisa, Rayile& Yu, Zhaoxia& Zhang, Xiangyang& Maimaitiyiming, Dilinuer& Huang, Lipeng& Hasim, Ayshamgul…[et al.]. The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two-Kidney One-Clip Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153630