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Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway
Joint Authors
Liou, An-Ting
Chen, Mei-Fang
Yang, Chu-Wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
Curcumin (diferuloylmethane) is a yellow-colored polyphenol with antiproliferative and proapoptotic activities to various types of cancer cells.
This study explored the mechanism by which curcumin induces p53-null hepatoma cell apoptosis.
Results.
AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment.
Conversely, PTEN was upregulated.
Subcellular fractionations revealed that the FOXO4 protein translocated from cytosol into the nucleus after curcumin treatment.
Overexpression of FOXO4 increases the sensitivity of Hep3B cells to curcumin.
Knockdown of the FOXO4 gene by siRNA inhibits the proapoptotic effects of curcumin on Hep3B cell.
Conclusions.
This study revealed the AKT/PTEN/FOXO4 pathway as a potential candidate of target for treatment of p53-null liver cancers.
American Psychological Association (APA)
Liou, An-Ting& Chen, Mei-Fang& Yang, Chu-Wen. 2017. Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153650
Modern Language Association (MLA)
Liou, An-Ting…[et al.]. Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153650
American Medical Association (AMA)
Liou, An-Ting& Chen, Mei-Fang& Yang, Chu-Wen. Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153650