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Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objective.
This study sought to explore the prognostic factors in a large retrospective cohort of patients with primary central nervous system lymphoma (PCNSL) from the Surveillance, Epidemiology, and End Results database.
Methods.
There were 5903 patients with PCNSL who had complete clinical information and were identified in the Surveillance, Epidemiology, and End Results program between 1973 and 2014.
The epidemiology, therapeutic measures, and clinical characteristics were listed as descriptive statistics.
They were grouped into 4 categories: immunocompetent individual with diffuse large B cell lymphoma (DLBCL), immunocompetent individual with non-DLBCL, immunocompromised individual with DLBCL, and immunocompromised individual with non-DLBCL based on different subtypes and immunological status.
Survival analysis was conducted with Cox regression models.
Results.
Different demographics and clinical characteristics were identified as independent factors in different groups.
In survival analysis, for patients with DLBCL, chemotherapy involving treatments was associated with the most favorable survival.
Received-only radiation could be considered as a primary treatment in immunocompetent patients with non-DLBCL.
These differences were statistically significant (P<0.05).
Conclusion.
PCNSL patients treated with appropriate chemotherapy treatments may receive stable tumor control.
American Psychological Association (APA)
Shan, Yudong& Hu, Yilan. 2018. Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study. Disease Markers،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1153666
Modern Language Association (MLA)
Shan, Yudong& Hu, Yilan. Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study. Disease Markers No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1153666
American Medical Association (AMA)
Shan, Yudong& Hu, Yilan. Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1153666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153666