![](/images/graphics-bg.png)
Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-01
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
In East Asian traditional medicine, Pulsatillae Radix (PR) is widely used to treat amoebic dysentery and renowned for its anti-inflammatory effects.
This study aimed to confirm evidence regarding the potential therapeutic effect of PR on Crohn’s disease using a system network level based in silico approach.
Study results showed that the compounds in PR are highly connected to Crohn’s disease related pathways, biological processes, and organs, and these findings were confirmed by compound-target network, target-pathway network, and gene ontology analysis.
Most compounds in PR have been reported to possess anti-inflammatory, anticancer, and antioxidant effects, and we found that these compounds interact with multiple targets in a synergetic way.
Furthermore, the mRNA expressions of genes targeted by PR are elevated significantly in immunity-related organ tissues, small intestine, and colon.
Our results suggest that the anti-inflammatory and repair and immune system enhancing effects of PR might have therapeutic impact on Crohn’s disease.
American Psychological Association (APA)
Suh, Su Yeon& An, Won G.. 2017. Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1153683
Modern Language Association (MLA)
Suh, Su Yeon& An, Won G.. Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1153683
American Medical Association (AMA)
Suh, Su Yeon& An, Won G.. Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1153683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153683