Solanum paranense Extracts and Solanine Present Anti-Inflammatory Activity in an Acute Skin Inflammation Model in Mice
Joint Authors
Boligon, Aline Augusti
Piana, Mariana
Camponogara, Camila
Oliveira, Sara Marchesan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the study was to evaluate the anti-inflammatory activity of the S.
paranense crude extract, S.
paranense alkaloid fraction, and solanine alkaloid.
These samples reduce the croton oil-induced ear edema in a dose-dependent manner and a maximum inhibition of 81%, 98%, and 80% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively.
Moreover, the samples inhibit the MPO activity with an inhibition maximum of 51%, 40%, and 46% in the doses of 1.0, 0.73, and 0.37 mg/ear, respectively.
Similar results were found for dexamethasone 0.10 mg/ear (positive control), which showed inhibitions of ear edema and MPO activity of 100% and 65%, respectively.
These results found probably are related to the presence of solanine which is present in significant quantity in the alkaloid fraction and others as rutin and rosmarinic, chlorogenic, and gallic acids.
These results support the use of S.
paranense for the treatment of inflammatory skin disorders.
American Psychological Association (APA)
Piana, Mariana& Camponogara, Camila& Boligon, Aline Augusti& Oliveira, Sara Marchesan. 2017. Solanum paranense Extracts and Solanine Present Anti-Inflammatory Activity in an Acute Skin Inflammation Model in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153714
Modern Language Association (MLA)
Piana, Mariana…[et al.]. Solanum paranense Extracts and Solanine Present Anti-Inflammatory Activity in an Acute Skin Inflammation Model in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153714
American Medical Association (AMA)
Piana, Mariana& Camponogara, Camila& Boligon, Aline Augusti& Oliveira, Sara Marchesan. Solanum paranense Extracts and Solanine Present Anti-Inflammatory Activity in an Acute Skin Inflammation Model in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153714