ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population
Joint Authors
Zhang, Li
Gu, Xiaoqiong
Che, Di
Xu, Yufen
Pi, Lei
Fang, Zhenzhen
Cai, Minmin
Fu, Lanyan
Zhou, Huazhong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ATP-binding cassette subfamily C member 4 (ABCC4) gene in most European populations.
However, significant differences exist among ethnic populations in European and Chinese subjects; therefore, whether ABCC4 variants indicate susceptibility to KD in Chinese children is unclear.
The purpose of this research was to evaluate correlations between ABCC4 gene polymorphisms and susceptibility to KD in a Southern Chinese population.
We genotyped six polymorphisms (rs7986087, rs868853, rs3765534, rs1751034, rs3742106, and rs9561778) in 775 KD patients and 774 healthy controls.
Ninety-five percent confidence intervals (95% CIs) and odds ratios (ORs) were used to assess the strength of each association.
We found that the rs7986087 T variant genotype was associated with significantly higher susceptibility to KD (adjusted OR = 1.30, 95% CI = 1.05–1.60 for rs7986087 CT/TT).
However, the rs868853 T variant genotype was associated with significantly lower susceptibility to KD (adjusted OR = 0.74, 95% CI = 0.59–0.92 for rs868853 CT/CC).
Compared with the patients with 0–4 ABCC4 risk genotypes, the patients with 5-6 ABCC4 risk genotypes had a significantly increased risk of KD (adjusted OR = 1.63, 95% CI = 1.07–2.47), and this risk was more significant in the subgroups of females, subjects aged 12–60 months, and individuals with coronary artery lesions.
These results indicate that specific single-nucleotide polymorphisms in the ABCC4 gene may increase susceptibility to KD in a Southern Chinese population.
American Psychological Association (APA)
Che, Di& Pi, Lei& Fang, Zhenzhen& Xu, Yufen& Cai, Minmin& Fu, Lanyan…[et al.]. 2018. ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153717
Modern Language Association (MLA)
Che, Di…[et al.]. ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153717
American Medical Association (AMA)
Che, Di& Pi, Lei& Fang, Zhenzhen& Xu, Yufen& Cai, Minmin& Fu, Lanyan…[et al.]. ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153717