Urinary Clusterin Is Upregulated in Nephropathia Epidemica
Joint Authors
Khaiboullina, Svetlana F.
Martynova, Ekaterina V.
Anokhin, Vladimir V.
Valiullina, Aygul H.
Garanina, Ekaterina E.
Shakirova, Venera G.
Khaertynova, Ilsiyar
Abdulkhakov, Sayar
Maksudova, Adelya N.
Ivanova, Vilena V.
Abiola, Ilesanmi M.
Tazetdinova, Leisan G.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Kidney insufficiency is a hallmark of nephropathia epidemica (NE).
Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue.
We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2.
To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency.
Analysis of 12 biomarkers suggests damage to the kidney proximal tubule at the onset of NE.
Also, upregulation of biomarkers of inflammation and leukocyte chemotaxis were detected in NE urine.
Furthermore, increased clusterin levels were found in early- and late-phase NE urine.
Comparative analysis revealed that clusterin is a biomarker, upregulated in NE urine.
American Psychological Association (APA)
Martynova, Ekaterina V.& Maksudova, Adelya N.& Shakirova, Venera G.& Abdulkhakov, Sayar& Khaertynova, Ilsiyar& Anokhin, Vladimir V.…[et al.]. 2018. Urinary Clusterin Is Upregulated in Nephropathia Epidemica. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153718
Modern Language Association (MLA)
Martynova, Ekaterina V.…[et al.]. Urinary Clusterin Is Upregulated in Nephropathia Epidemica. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153718
American Medical Association (AMA)
Martynova, Ekaterina V.& Maksudova, Adelya N.& Shakirova, Venera G.& Abdulkhakov, Sayar& Khaertynova, Ilsiyar& Anokhin, Vladimir V.…[et al.]. Urinary Clusterin Is Upregulated in Nephropathia Epidemica. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153718
