Antiobesity Activities of Methanolic Extracts of Amaranthus dubius, Cucurbita pepo, and Vigna unguiculata in Progesterone-Induced Obese Mice
Joint Authors
Ngugi, Mathew Piero
Nderitu, Kathryn Wanjiku
Mwenda, Njagi Shadrack
Macharia, Ndegwa John
Barasa, Stephen Super
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Amaranthus dubius, Vigna unguiculata, and Cucurbita pepo are traditionally used to manage obesity in Kenya but lack scientific validation to support their use.
The aim of this study was to determine the antiobesity activity of methanolic leaf extracts of these plants in progesterone-induced obese mice.
The activity of the methanolic leaf extracts was orally bioscreened in progesterone-induced obese mice at 200 mg/kg/bw and 400 mg/kg/bw.
Body mass index was calculated once per week for four weeks and blood samples were obtained at the end of the experiment for lipid profile analysis.
Antiobesity activities of the extracts were compared with the controls.
Leaf extracts of A.
dubius, C.
pepo, and V.
unguiculata, at dose concentrations of 200 mg/kgbw and 400 mg/kgbw, showed significant effects on body mass index (p<0.05).
There was no significant difference between the three extracts on lipid parameter profiles (p>0.05).
The present study showed high food intake in the negative control group as compared with normal control, positive control, and treatment groups.
These extracts contained various phytochemicals such as saponins, flavonoids, alkaloids, and steroids and therefore validate use of aforementioned plants in the suppression of obesity and their use for management of obesity is recommended.
American Psychological Association (APA)
Nderitu, Kathryn Wanjiku& Mwenda, Njagi Shadrack& Macharia, Ndegwa John& Barasa, Stephen Super& Ngugi, Mathew Piero. 2017. Antiobesity Activities of Methanolic Extracts of Amaranthus dubius, Cucurbita pepo, and Vigna unguiculata in Progesterone-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153719
Modern Language Association (MLA)
Nderitu, Kathryn Wanjiku…[et al.]. Antiobesity Activities of Methanolic Extracts of Amaranthus dubius, Cucurbita pepo, and Vigna unguiculata in Progesterone-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153719
American Medical Association (AMA)
Nderitu, Kathryn Wanjiku& Mwenda, Njagi Shadrack& Macharia, Ndegwa John& Barasa, Stephen Super& Ngugi, Mathew Piero. Antiobesity Activities of Methanolic Extracts of Amaranthus dubius, Cucurbita pepo, and Vigna unguiculata in Progesterone-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153719