Glucose Metabolic Changes in the Brain and Muscles of Patients with Nonspecific Neck Pain Treated by Spinal Manipulation Therapy: A [18F]FDG PET Study
Joint Authors
Inami, Akie
Ogura, Takeshi
Watanuki, Shoichi
Masud, Md. Mehedi
Shibuya, Katsuhiko
Miyake, Masayasu
Matsuda, Rin
Hiraoka, Kotaro
Itoh, Masatoshi
Fuhr, Arlan W.
Yanai, Kazuhiko
Tashiro, Manabu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of this study was to investigate changes in brain and muscle glucose metabolism that are not yet known, using positron emission tomography with [18F]fluorodeoxyglucose ([18F]FDG PET).
Methods.
Twenty-one male volunteers were recruited for the present study.
[18F]FDG PET scanning was performed twice on each subject: once after the spinal manipulation therapy (SMT) intervention (treatment condition) and once after resting (control condition).
We performed the SMT intervention using an adjustment device.
Glucose metabolism of the brain and skeletal muscles was measured and compared between the two conditions.
In addition, we measured salivary amylase level as an index of autonomic nervous system (ANS) activity, as well as muscle tension and subjective pain intensity in each subject.
Results.
Changes in brain activity after SMT included activation of the dorsal anterior cingulate cortex, cerebellar vermis, and somatosensory association cortex and deactivation of the prefrontal cortex and temporal sites.
Glucose uptake in skeletal muscles showed a trend toward decreased metabolism after SMT, although the difference was not significant.
Other measurements indicated relaxation of cervical muscle tension, decrease in salivary amylase level (suppression of sympathetic nerve activity), and pain relief after SMT.
Conclusion.
Brain processing after SMT may lead to physiological relaxation via a decrease in sympathetic nerve activity.
American Psychological Association (APA)
Inami, Akie& Ogura, Takeshi& Watanuki, Shoichi& Masud, Md. Mehedi& Shibuya, Katsuhiko& Miyake, Masayasu…[et al.]. 2017. Glucose Metabolic Changes in the Brain and Muscles of Patients with Nonspecific Neck Pain Treated by Spinal Manipulation Therapy: A [18F]FDG PET Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153722
Modern Language Association (MLA)
Inami, Akie…[et al.]. Glucose Metabolic Changes in the Brain and Muscles of Patients with Nonspecific Neck Pain Treated by Spinal Manipulation Therapy: A [18F]FDG PET Study. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153722
American Medical Association (AMA)
Inami, Akie& Ogura, Takeshi& Watanuki, Shoichi& Masud, Md. Mehedi& Shibuya, Katsuhiko& Miyake, Masayasu…[et al.]. Glucose Metabolic Changes in the Brain and Muscles of Patients with Nonspecific Neck Pain Treated by Spinal Manipulation Therapy: A [18F]FDG PET Study. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153722