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Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus
Joint Authors
Pu, Chun
Zhang, Peng
Huang, Jian-Jun
Cheng, Long
Feng, Gang
Zhao, Jin-Song
Jin, Hui-Xiang
Gao, Jia-Lin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Extracellular superoxide dismutase (ecSOD) is the major extracellular scavenger of reactive oxygen species and associated with the diabetic complication in patients with type 2 diabetes mellitus (T2DM).
We aimed to investigate the serum ecSOD activity in Chinese patients with different stages of diabetic retinopathy (DR) and evaluate the association between the serum ecSOD activity and the severity of DR.
A total of 343 T2DM patients were categorized into three groups: nondiabetic retinopathy (NDR) group, nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group.
Serum ecSOD activities were measured by the autoxidation of the pyrogallol method.
In this study, 271, 46, and 26 patients were enrolled in the NDR, NPDR, and PDR groups, respectively.
We found a significantly decreased trend of serum ecSOD activity among NDR subjects (118.0 ± 11.5 U/mL) compared to NPDR subjects (108.5 ± 11.9 U/mL) (P<0.001) and NPDR subjects compared to PDR subjects (102.7 ± 12.4 U/mL) (P=0.041).
Serum ecSOD activity was an independent risk factor for DR (OR = 0.920, P<0.001) and was associated with the progression of DR.
Serum ecSOD activity might be a biomarker for DR screening and evaluation of the clinical severity of DR in Chinese T2DM patients.
American Psychological Association (APA)
Zhao, Jin-Song& Jin, Hui-Xiang& Gao, Jia-Lin& Pu, Chun& Zhang, Peng& Huang, Jian-Jun…[et al.]. 2018. Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153723
Modern Language Association (MLA)
Zhao, Jin-Song…[et al.]. Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153723
American Medical Association (AMA)
Zhao, Jin-Song& Jin, Hui-Xiang& Gao, Jia-Lin& Pu, Chun& Zhang, Peng& Huang, Jian-Jun…[et al.]. Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153723