![](/images/graphics-bg.png)
Manual Acupuncture at PC6 Ameliorates Acute Restraint Stress-Induced Anxiety in Rats by Normalizing Amygdaloid Noradrenergic Response
Joint Authors
Lee, Bong Hyo
Zhao, ZhengLin
Zhang, Jie
Zhao, RongJie
Song, Chang Hyun
Liu, HongFeng
Wang, YuHua
Wu, YiYan
Kim, Sang Chan
Yang, Chae Ha
Cho, Il Je
Lee, Chul Won
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acupuncture improves ethanol withdrawal-induced anxiety in rats in an acupoint-dependent manner.
Thus, the present study investigated the effects of acupuncture on acute restraint stress- (ARS-) induced anxiety.
Male rats were exposed to ARS for 3 h followed by acupuncture at either PC6 (Neiguan), HT7 (Shenmen), or a nonacupoint (tail) once a day for three consecutive days.
Five minutes after the third acupuncture treatment, anxiety-like behavior was evaluated in an elevated plus maze (EPM).
Additionally, plasma corticosterone (CORT) levels were measured by radioimmunoassay and the concentrations of norepinephrine (NE) and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in the central nucleus of the amygdala (CeA) were determined using high-performance liquid chromatography.
Acupuncture at PC6, but not HT7 or a nonacupoint, attenuated anxiety-like behavior, but this attenuation was abolished by a postacupunctural intra-CeA infusion of NE.
Acupuncture at PC6 also reduced the oversecretion of plasma CORT and inhibited increases in amygdaloid NE and MHPG induced by ARS.
Further, Western blot analyses and real-time polymerase chain reaction assays revealed that acupuncture at PC6 prevented ARS-induced enhancements in the protein and mRNA expressions of tyrosine hydroxylase in the CeA.
These results suggest that acupuncture performed specifically at acupoint PC6 reduces ARS-induced anxiety-like behavior by dampening amygdaloid noradrenergic responses.
American Psychological Association (APA)
Zhao, ZhengLin& Kim, Sang Chan& Liu, HongFeng& Zhang, Jie& Wang, YuHua& Cho, Il Je…[et al.]. 2017. Manual Acupuncture at PC6 Ameliorates Acute Restraint Stress-Induced Anxiety in Rats by Normalizing Amygdaloid Noradrenergic Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153724
Modern Language Association (MLA)
Zhao, ZhengLin…[et al.]. Manual Acupuncture at PC6 Ameliorates Acute Restraint Stress-Induced Anxiety in Rats by Normalizing Amygdaloid Noradrenergic Response. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153724
American Medical Association (AMA)
Zhao, ZhengLin& Kim, Sang Chan& Liu, HongFeng& Zhang, Jie& Wang, YuHua& Cho, Il Je…[et al.]. Manual Acupuncture at PC6 Ameliorates Acute Restraint Stress-Induced Anxiety in Rats by Normalizing Amygdaloid Noradrenergic Response. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153724