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Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma
Joint Authors
Zhou, Jundong
Xia, Xiaochun
He, Chao
Wu, Anqing
Wu, Jinchang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization.
The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients.
The expression of MAP4 protein was analyzed using immunohistochemistry.
The clinical significance and the prognostic significance of MAP4 expression were assessed by Kaplan-Meier analysis and Cox regression analysis.
The roles of MAP4 in the migration and invasion of LADC cells were detected by wound-healing assays and transwell assays, respectively.
We found the expression levels of MAP4 protein in LADC tissues to be significantly higher than those in noncancerous tissues.
MAP4 expression was significantly correlated with differentiation, pathological T stage, and TNM stage.
Kaplan-Meier survival analysis indicated that patients with high MAP4 expression had significantly poorer overall survival (OS).
Cox regression analysis revealed that MAP4 expression level was an independent prognostic factor for OS.
Functionally, in vitro studies showed that MAP4 knockdown efficiently suppressed the migration and invasion of LADC cells.
Our data indicated that MAP4 protein may represent a novel prognostic biomarker and a potential therapeutic target for LADC.
American Psychological Association (APA)
Xia, Xiaochun& He, Chao& Wu, Anqing& Zhou, Jundong& Wu, Jinchang. 2018. Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153733
Modern Language Association (MLA)
Xia, Xiaochun…[et al.]. Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153733
American Medical Association (AMA)
Xia, Xiaochun& He, Chao& Wu, Anqing& Zhou, Jundong& Wu, Jinchang. Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153733