Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica)‎ in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet

Joint Authors

Lim, Soon Sung
Kang, Il Jun
Hwang, Seung Hwan

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-02-20

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

The objective of the present study was to evaluate α-glucosidase inhibitory and antidiabetic effects of Nopal water extract (NPWE) and Nopal dry power (NADP) in low-dose streptozotocin- (STZ-) induced diabetic rats fed a high-fat diet (HFD).

The type 2 diabetic rat model was induced by HFD and low-dose STZ.

The rats were divided into four groups as follows: (1) nondiabetic rats fed a regular diet (RD-Control); (2) low-dose STZ-induced diabetic rats fed HFD (HF-STZ-Control); (3) low-dose STZ-induced diabetic rats fed HFD and supplemented with NPWE (100 mg/kg body weight, HF-STZ-NPWE); and (4) low-dose STZ-induced diabetic rats fed HFD and supplemented with comparison medication (rosiglitazone, 10 mg/kg, body weight, HF-STZ-Rosiglitazone).

In results, NPWE and NADP had IC50 values of 67.33 and 86.68 μg/mL, both of which exhibit inhibitory activities but lower than that of acarbose (38.05 μg/mL) while NPWE group significantly decreased blood glucose levels compared to control and NPDP group on glucose tolerance in the high-fat diet fed rats model ( P < 0.05 ).

Also, the blood glucose levels of HR-STZ-NPWE group were significantly lower ( P < 0.05 ) than HR-STZ-Control group on low-dose STZ-induced diabetic rats fed HFD.

Based on these findings, we suggested that NPWE could be considered for the prevention and/or treatment of blood glucose and a potential use as a dietary supplement.

American Psychological Association (APA)

Hwang, Seung Hwan& Kang, Il Jun& Lim, Soon Sung. 2017. Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153736

Modern Language Association (MLA)

Hwang, Seung Hwan…[et al.]. Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153736

American Medical Association (AMA)

Hwang, Seung Hwan& Kang, Il Jun& Lim, Soon Sung. Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153736

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1153736