Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children
Joint Authors
Goncalves, Marilda Souza
Santiago, Rayra Pereira
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Fonseca, Cleverson Alves
Adorno, Elisângela Vitoria
Guarda, Caroline Conceição
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Carvalho, Suellen Pinheiro
da Paz, Silvana Souza
de Miranda, Fernando Nunes
Barbosa, Cynara Gomes
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The nonracial leukopenia may be a result of exposure to polycyclic derivatives (benzene-toluene-xylene (BTX)) and may arise from a possible change in the bone marrow microenvironment.
The present study sought to evaluate the association of genetic polymorphisms in xenobiotic-metabolizing enzymes with hematological and biochemical profiles.
Methods.
We evaluated 89 African descendant children, exposed indirectly to benzene derivatives.
Laboratory parameters were investigated by automated methods and genetic polymorphisms by PCR-RFLP and PCR multiplex.
Results.
Children with leukopenia had significantly decreased white blood cells (WBCs) and platelet counts, which is not consistent with benign leukopenia.
In the same group, we have found that carriers of the CYP2E1 variant allele had decreased WBC and lymphocytes.
Those with NQO1 variant allele had decreased WBC, neutrophil, eosinophil, monocyte, and lymphocyte counts.
Carriers of the MPO variant allele had decreased WBC, neutrophil, eosinophil, basophil, monocyte, lymphocyte, and platelet counts and an elevated free iron level.
Children with GSTT and GSTM null exhibited decreased WBC, neutrophil, basophil, and lymphocyte counts.
Our multivariate analysis model reveals that females were independently associated with leukopenia.
Conclusion.
Our results suggest that the polymorphisms investigated were associated with hematological changes in the studied population.
These alterations could be heightened by exposure to benzene derivatives.
American Psychological Association (APA)
Oliveira, Rodrigo Mota& Figueiredo, Camylla Vilas Boas& Santiago, Rayra Pereira& Yahouédéhou, Sètondji Cocou Modeste Alexandre& Carvalho, Suellen Pinheiro& da Paz, Silvana Souza…[et al.]. 2018. Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153739
Modern Language Association (MLA)
Oliveira, Rodrigo Mota…[et al.]. Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153739
American Medical Association (AMA)
Oliveira, Rodrigo Mota& Figueiredo, Camylla Vilas Boas& Santiago, Rayra Pereira& Yahouédéhou, Sètondji Cocou Modeste Alexandre& Carvalho, Suellen Pinheiro& da Paz, Silvana Souza…[et al.]. Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153739