Predictive Value of Procalcitonin for Bacterial Infection after Transarterial Chemoembolization or Radiofrequency Ablation for Hepatocellular Carcinoma
Joint Authors
Myung, Dae-Seong
Jang, Mi-Ok
Kang, Seung-Ji
Cho, Sung-Bum
Joo, Young-Eun
Kim, Uh Jin
Kim, Seong Eun
Park, Kyung-Hwa
Jung, Sook-In
An, Joon Hwan
Jang, Hee-Chang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This prospective observational study aimed at investigating the role of procalcitonin (PCT) in diagnosing bacterial infection and guiding antibiotic therapy for hepatocellular carcinoma (HCC) patients with fever after transarterial chemoembolization (TACE) and/or radiofrequency ablation (RFA).
Ninety-seven cases (84 patients) were enrolled.
Serum PCT, C-reactive protein (CRP), and white blood cell (WBC) counts were measured on the day of fever onset (day 0) and days 1, 3, 5, and 7 of fever.
Empirical antibiotics were initiated only if PCT was ≥0.5 ng/mL or specific infection foci were suspected.
An infectious cause was found in nine cases.
PCT on day 0 of fever was significantly higher in patients with bacterial infection than in those without infection (P=0.035).
The area under the receiver operating characteristic curve for PCT was 0.715 (95% confidence interval, 0.538–0.892) and was higher than that for CRP (0.598 (0.368–0.828)) or WBC counts (0.502 (0.307–0.697)).
In patients undergoing TACE and/or RFA, a significantly lower number of antibiotics were prescribed during the study period than during the prestudy period (P<0.001).
In conclusion, PCT might be a biomarker for diagnosing infection and guiding antibiotic treatment to reduce unnecessary antibiotic use in patients with fever after TACE and/or RFA.
American Psychological Association (APA)
Kang, Seung-Ji& Kim, Uh Jin& Kim, Seong Eun& An, Joon Hwan& Jang, Mi-Ok& Myung, Dae-Seong…[et al.]. 2018. Predictive Value of Procalcitonin for Bacterial Infection after Transarterial Chemoembolization or Radiofrequency Ablation for Hepatocellular Carcinoma. Disease Markers،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153740
Modern Language Association (MLA)
Kang, Seung-Ji…[et al.]. Predictive Value of Procalcitonin for Bacterial Infection after Transarterial Chemoembolization or Radiofrequency Ablation for Hepatocellular Carcinoma. Disease Markers No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153740
American Medical Association (AMA)
Kang, Seung-Ji& Kim, Uh Jin& Kim, Seong Eun& An, Joon Hwan& Jang, Mi-Ok& Myung, Dae-Seong…[et al.]. Predictive Value of Procalcitonin for Bacterial Infection after Transarterial Chemoembolization or Radiofrequency Ablation for Hepatocellular Carcinoma. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153740