Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy
Joint Authors
Bedini, Nice
Cicchetti, Alessandro
Palorini, Federica
Magnani, Tiziana
Zuco, Valentina
Pennati, Marzia
Campi, Elisa
Pesce, Samantha
Villa, Sergio
Avuzzi, Barbara
Morlino, Sara
Visentin, Maria Emanuela
Zaffaroni, Nadia
Rancati, Tiziana
Valdagni, Riccardo
Allavena, P.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A recent “hot topic” in prostate cancer radiotherapy is the observed association between acute/late rectal toxicity and the presence of abdominal surgery before radiotherapy.
The exact mechanism is unclear.
Our working hypothesis was that a previous surgery may influence plasma level of inflammatory molecules and this might result in enhanced radiosensitivity.
We here present results on the feasibility of monitoring the expression of inflammatory molecules during radiotherapy.
Plasma levels of a panel of soluble mediators associated with the inflammatory response were measured in prostate cancer patients undergoing radical radiotherapy.
We measured 3 cytokines (IL-1b, IL-6, and TNF alpha), 2 chemokines (CCL2 and CXCL8), and the long pentraxin PTX3.
20 patients were enrolled in this feasibility evaluation.
All patients were treated with IMRT at 78 Gy.
3/20 patients reported grade 2 acute rectal toxicity, while 4/20 were scored as grade 2 late toxicity.
CCL2 was the most interesting marker showing significant increase during and after radiotherapy.
CCL2 levels at radiotherapy end could be modelled using linear regression including basal CCL2, age, surgery, hypertension, and use of anticoagulants.
The 4 patients with late toxicity had CCL2 values at radiotherapy end above the median value.
This trial is registered with ISRCTN64979094.
American Psychological Association (APA)
Bedini, Nice& Cicchetti, Alessandro& Palorini, Federica& Magnani, Tiziana& Zuco, Valentina& Pennati, Marzia…[et al.]. 2018. Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153741
Modern Language Association (MLA)
Bedini, Nice…[et al.]. Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153741
American Medical Association (AMA)
Bedini, Nice& Cicchetti, Alessandro& Palorini, Federica& Magnani, Tiziana& Zuco, Valentina& Pennati, Marzia…[et al.]. Evaluation of Mediators Associated with the Inflammatory Response in Prostate Cancer Patients Undergoing Radiotherapy. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153741