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Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells
Joint Authors
Lee, Jin-Seok
Lee, Sung-Bae
Kim, Won-Yong
Kim, Hyeong-Geug
Choi, Seung-Hoon
Son, Chang Gue
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The combination of Artemisia iwayomogi and Curcuma longa radix is frequently prescribed for liver diseases in TKM.
However, the synergic effects of the two herbs on nonalcoholic steatohepatitis (NASH) have not yet been studied.
Therefore, we investigated the anti-NASH effects of the water extract of A.
iwayomogi (AI), C.
longa radix (CL), and combination of the two herbs (ACE).
Hepatic steatosis and NASH were induced in HepG2 cells by treatment with palmitic acid (PA, for 6 h) with/without pretreatment of ACE (25 or 50 μg/mL), AI (50 or 100 μg/mL), CL (50 or 100 μg/mL), curcumin (5 μg/mL), or scopoletin (5 μg/mL).
The PA treatment (200 μM) drastically altered intracellular triglyceride levels, total cholesterol, and expression levels of genes related to lipid metabolism (CD36, SREBP1c, PPAR-γ, and PPAR-α), whereas pretreatment with ACE significantly attenuated these alterations.
ACE also protected HepG2 cells from PA- (300 μM-) induced endoplasmic reticulum (ER) stress and apoptosis and attenuated the related key molecules including GRP78, eIF2, and CHOP, respectively.
In conclusion, we found synergic effects of A.
iwayomogi and C.
longa on NASH, supporting the clinical potential for fatty liver disorders.
In addition, modulation of ER stress-relative molecules would be involved in its underlying mechanism.
American Psychological Association (APA)
Kim, Hyeong-Geug& Lee, Sung-Bae& Lee, Jin-Seok& Kim, Won-Yong& Choi, Seung-Hoon& Son, Chang Gue. 2017. Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153742
Modern Language Association (MLA)
Kim, Hyeong-Geug…[et al.]. Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153742
American Medical Association (AMA)
Kim, Hyeong-Geug& Lee, Sung-Bae& Lee, Jin-Seok& Kim, Won-Yong& Choi, Seung-Hoon& Son, Chang Gue. Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153742