Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35
Joint Authors
Diniz, Gulden
Bayrak Degirmenci, P.
Aksun, S.
Altin, Z.
Bilgir, F.
Arslan, I. B.
Colak, H.
Ural, B.
Ozdemir, B.
Kırmaz, C.
Solakoglu Kahraman, Dudu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches.
Methods.
IL-10, IL-17, TGF-β, IFN-γ, IL-22, and IL-35 serum levels of allergic rhinitis (AR) patients were measured using ELISA method.
Allergic sensitization was demonstrated by the skin prick test.
Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR).
Patients only with mite sensitivity were included in the study for perennial AR (PAR).
AR clinic severity was demonstrated by the nasal symptom scores (NSS).
Results.
In total, 65 AR patients (patient group), having 31 PAR and 34 SAR patients, and 31 healthy individuals (control group) participated in the study.
Cytokine levels between the patient group and the control group were compared; IL-17 (p=0.038), IL-22 (p=0.001), and TGF-β (p=0.031) were detected as high in the patient group, and IFN-γ (p<0.001) was detected as low in the patient group.
When correlation analysis was made between age, gender, prick test result, NSS, AR duration, and cytokine levels in the patient group, a negative correlation was detected only between IFN-γ (p=0.032/r=−0.266) level and NSS.
Conclusions.
Accompanied by the literature information, these results made us think that T cell subgroups and cytokines have an important role in AR immunopathogenesis.
It is thought that future studies to be conducted relating to this subject will form new targets in treatment.
American Psychological Association (APA)
Bayrak Degirmenci, P.& Aksun, S.& Altin, Z.& Bilgir, F.& Arslan, I. B.& Colak, H.…[et al.]. 2018. Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153743
Modern Language Association (MLA)
Bayrak Degirmenci, P.…[et al.]. Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153743
American Medical Association (AMA)
Bayrak Degirmenci, P.& Aksun, S.& Altin, Z.& Bilgir, F.& Arslan, I. B.& Colak, H.…[et al.]. Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153743