Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health
Joint Authors
Kim, Jeong Ah
Yu, Jae Young
Gupta, Biki
Park, Hyoung Geun
Son, Miwon
Jun, Joon-Ho
Yong, Chul Soon
Kim, Jong Oh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The proprietary DA-5512 formulation comprises six herbal extracts from traditional oriental plants historically associated with therapeutic and other applications related to hair.
Here, we investigated the effects of DA-5512 on the proliferation of human dermal papilla cells (hDPCs) in vitro and on hair growth in C57BL/6 mice and conducted a clinical study to evaluate the efficacy and safety of DA-5512.
DA-5512 significantly enhanced the viability of hDPCs in a dose-dependent manner (p<0.05), and 100 ppm of DA-5512 and 1 μM minoxidil (MXD) significantly increased the number of Ki-67-positive cells, compared with the control group (p<0.05).
MXD (3%) and DA-5512 (1%, 5%) significantly stimulated hair growth and increased the number and length of hair follicles (HFs) versus the controls (each p<0.05).
The groups treated with DA-5512 exhibited hair growth comparable to that induced by MXD.
In clinical study, we detected a statistically significant increase in the efficacy of DA-5512 after 16 weeks compared with the groups treated with placebo or 3% MXD (p<0.05).
In conclusion, DA-5512 might promote hair growth and enhance hair health and can therefore be considered an effective option for treating hair loss.
American Psychological Association (APA)
Yu, Jae Young& Gupta, Biki& Park, Hyoung Geun& Son, Miwon& Jun, Joon-Ho& Yong, Chul Soon…[et al.]. 2017. Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153748
Modern Language Association (MLA)
Yu, Jae Young…[et al.]. Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153748
American Medical Association (AMA)
Yu, Jae Young& Gupta, Biki& Park, Hyoung Geun& Son, Miwon& Jun, Joon-Ho& Yong, Chul Soon…[et al.]. Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153748