New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis
Joint Authors
Sainaghi, Pier Paolo
Bellan, Mattia
Castello, Luigi Mario
Avanzi, Gian Carlo
Pagani, Sara
Mauro, Daniele
Lewis, Myles J.
Nerviani, Alessandra
Pitzalis, Costantino
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rheumatoid Arthritis (RA) is the most common chronic inflammatory autoimmune disease involving joints.
Among several pathogenic mechanisms, the impairment of homeostatic regulators of inflammation seems to be critically important to sustain persistent infiltration and activation of immune and stromal cells within the diseased synovium.
Tyrosine kinase receptors Tyro3, Axl, and Mer are members of the TAM family.
Upon binding their ligands Growth Arrest-Specific gene 6 (Gas6) and Protein S (ProS1), TAM receptors (TAMs) exert numerous and diverse biologic functions.
Activated Axl and Mer, for instance, can negatively regulate the inflammatory cascade and mediate phagocytosis of apoptotic cells, contributing to prevent the development of autoimmunity.
Thus, a role for TAMs has been hypothesized in RA.
In this review, we will summarise unmet clinical needs in RA, depict the biology of TAMs and TAM ligands, focussing on their ability to regulate the immune system and inflammation cascade, and finally offer an overview of the state-of-the-art literature about the putative role of TAM axis in RA.
American Psychological Association (APA)
Pagani, Sara& Bellan, Mattia& Mauro, Daniele& Castello, Luigi Mario& Avanzi, Gian Carlo& Lewis, Myles J.…[et al.]. 2020. New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153759
Modern Language Association (MLA)
Pagani, Sara…[et al.]. New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153759
American Medical Association (AMA)
Pagani, Sara& Bellan, Mattia& Mauro, Daniele& Castello, Luigi Mario& Avanzi, Gian Carlo& Lewis, Myles J.…[et al.]. New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153759