Associations of Small Fiber Neuropathy with Geriatric Nutritional Risk Index and Arterial Stiffness in Hemodialysis
Joint Authors
Wu, Pei-Yu
Kuo, Mei-Chuan
Huang, Jiun-Chi
Mai, Hsiu-Chin
Chen, Szu-Chia
Chiu, Yi-Wen
Chang, Jer-Ming
Chen, Hung-Chun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Peripheral neuropathy is a common neurological complication in uremic patients, and quantitative sensory testing (QST) is effective for diagnosis of small fiber neuropathy.
Malnutrition and arterial stiffness are prevalent in patients undergoing hemodialysis (HD).
The associations of small fiber neuropathy with nutritional status and arterial stiffness remain uncertain in maintenance HD patients.
Methods.
A total of 152 HD patients were included.
Geriatric nutritional risk index (GNRI), an indicator of nutritional status, was calculated by serum albumin and actual and ideal body weight.
Arterial stiffness was defined as brachial-ankle pulse wave velocity baPWV>1400 cm/s.
Small fiber neuropathy was assessed by an abnormal QST threshold of cold and warm sensation in patients’ hands or feet.
Multivariate forward logistic regression analysis was performed to examine the associations among abnormal QST threshold, GNRI, and arterial stiffness.
Results.
baPWV and prevalence of abnormal QST threshold were significantly higher in diabetic patients.
Multivariate logistic analyses revealed that older age (OR, 1.081; 95% CI, 1.026–1.139, p=0.003) and male gender (OR, 4.450; 95% CI, 1.250–15.836, p=0.021) were associated with abnormal warm threshold of hands.
Furthermore, diabetes (OR, 3.966; 95% CI, 1.351–11.819, p=0.012) and lower GNRI (per 1 unit increase, OR, 0.935, 95% CI, 0.887–0.985, p=0.012) were associated with abnormal cold threshold of feet.
Arterial stiffness (OR, 5.479, 95% CI, 1.132–22.870, p=0.020) and higher calcium-phosphorus product (OR, 1.071, 95% CI, 1.013–1.132, p=0.015) were associated with abnormal warm threshold of feet.
Conclusions.
Lower GNRI and arterial stiffness were significantly associated with small fiber neuropathy in patients undergoing HD.
Malnutrition risk and vascular factors might play important roles in small fiber neuropathy among patients undergoing HD.
American Psychological Association (APA)
Kuo, Mei-Chuan& Huang, Jiun-Chi& Wu, Pei-Yu& Mai, Hsiu-Chin& Chen, Szu-Chia& Chiu, Yi-Wen…[et al.]. 2020. Associations of Small Fiber Neuropathy with Geriatric Nutritional Risk Index and Arterial Stiffness in Hemodialysis. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153762
Modern Language Association (MLA)
Kuo, Mei-Chuan…[et al.]. Associations of Small Fiber Neuropathy with Geriatric Nutritional Risk Index and Arterial Stiffness in Hemodialysis. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153762
American Medical Association (AMA)
Kuo, Mei-Chuan& Huang, Jiun-Chi& Wu, Pei-Yu& Mai, Hsiu-Chin& Chen, Szu-Chia& Chiu, Yi-Wen…[et al.]. Associations of Small Fiber Neuropathy with Geriatric Nutritional Risk Index and Arterial Stiffness in Hemodialysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153762