Prognostic and Clinicopathological Significance of PD-L1 in Patients with Cholangiocarcinoma: A Meta-Analysis
Joint Authors
Xie, Qinfen
Zheng, Shusen
Wang, Lidong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
In recent years, there is growing literature on the prognostic significance of programmed death-ligand 1 (PD-L1) in cholangiocarcinoma (CCA); however, data have been conflicting.
Therefore, the objective of this study was to assess the correlation between PD-L1 and prognosis in CCA through meta-analysis.
Methods.
Published studies were retrieved from the Web of Science, PubMed, Embase, and Cochrane Library up to April 17, 2020.
The relationships between PD-L1 expression and survival outcomes were assessed using hazard ratios (HRs) and 95% confidence intervals (CIs).
Results.
Eighteen studies consisting of 2012 patients were included.
Overexpression of PD-L1 was significantly associated with worse overall survival (OS) (HR=1.58, 95%CI=1.30−1.92, p<0.001) but not with poor disease-free survival (DFS) (HR=1.03, 95%CI=0.68−1.55, p=0.895) in CCA.
Moreover, PD-L1 was associated with low differentiation (OR=1.43, 95%CI=1.09−1.87, p=0.010) and higher pN stage (OR=1.45, 95%CI=1.10−1.92, p=0.009) but not with sex, TNM stage, vascular invasion, perineural invasion, age, or tumor size.
Conclusion.
High PD-L1 expression was associated with worse OS, poor differentiation, and higher pN stage in patients with CCA.
PD-L1 could be a potential prognostic marker in CCA.
American Psychological Association (APA)
Xie, Qinfen& Wang, Lidong& Zheng, Shusen. 2020. Prognostic and Clinicopathological Significance of PD-L1 in Patients with Cholangiocarcinoma: A Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1153766
Modern Language Association (MLA)
Xie, Qinfen…[et al.]. Prognostic and Clinicopathological Significance of PD-L1 in Patients with Cholangiocarcinoma: A Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1153766
American Medical Association (AMA)
Xie, Qinfen& Wang, Lidong& Zheng, Shusen. Prognostic and Clinicopathological Significance of PD-L1 in Patients with Cholangiocarcinoma: A Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1153766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153766