![](/images/graphics-bg.png)
Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population
Joint Authors
Aziz, Wajahat
Bhatti, Attya
Feingold, Eleanor
John, Peter
Aslam, Muhammad Muaaz
Fan, Kang-Hsien
Ahmed, Bashir
Kamboh, M. Ilyas
Demirci, F. Yesim
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a complex and multifactorial autoimmune disorder with the involvement of multiple genetic and environmental factors.
Genome-wide association studies (GWAS) have identified more than 50 RA genetic loci in European populations.
Given the anticipated overlap of RA-relevant genes and pathways across different ethnic groups, we sought to replicate 58 GWAS-implicated SNPs reported in Europeans in Pakistani subjects.
1,959 unrelated subjects comprising 1,222 RA cases and 737 controls were collected from three rheumatology facilities in Pakistan.
Genotyping was performed using iPLEX or TaqMan® methods.
A total of 50 SNPs were included in the final association analysis after excluding those that failed assay design/run or postrun QC analysis.
Fourteen SNPs (LINC00824/rs1516971, PADI4/rs2240336, CEP57/rs4409785, CTLA4/rs3087243, STAT4/rs13426947, HLA-B/MICA/rs2596565, C5orf30/rs26232, CCL21/rs951005, GATA3/rs2275806, VPS37C/rs595158, HLA-DRB1/rs660895, EOMES/rs3806624, SPRED2/rs934734, and RUNX1/rs9979383) were replicated in our Pakistani sample at false discovery rate (FDR) of <0.20 with nominal p values ranging from 4.73E-06 to 3.48E-02.
Our results indicate that several RA susceptibility loci are shared between Pakistani and European populations, supporting the role of common genes/pathways.
American Psychological Association (APA)
Aslam, Muhammad Muaaz& John, Peter& Fan, Kang-Hsien& Bhatti, Attya& Aziz, Wajahat& Ahmed, Bashir…[et al.]. 2020. Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153768
Modern Language Association (MLA)
Aslam, Muhammad Muaaz…[et al.]. Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153768
American Medical Association (AMA)
Aslam, Muhammad Muaaz& John, Peter& Fan, Kang-Hsien& Bhatti, Attya& Aziz, Wajahat& Ahmed, Bashir…[et al.]. Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153768