KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAKSTAT3 Signaling Pathway

Joint Authors

Du, Xianghui
Di, Jun
Ji, Zhiyu
Mi, Aoning
Li, Quanying
Wang, Anpeng
Wang, Anlian
Qin, Changjiang
Zhang, Qi

Source

Disease Markers

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-07-09

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies.

However, the role of KIF20A in colorectal cancer (CRC) is still unclear.

This study is aimed at investigating the potential roles of KIF20A in the development of CRC.

The results of bioinformatics analysis, immunohistochemical staining, and Western blot analysis showed that KIF20A was overexpressed in CRC tissues compared with adjacent normal tissues.

High expression of KIF20A in CRC tissues was associated with depth of invasion, lymphatic node metastasis, distant metastasis, and TNM stage.

Moreover, the Kaplan-Meier survival analysis showed that CRC patients with high KIF20A expression had poor prognoses.

Cox regression analysis revealed that KIF20A was an independent prognostic factor in patients with CRC.

Further studies suggested that knockdown of KIF20A was able to reduce cell proliferation and migration by inhibiting the JAK/STAT3 pathway.

Taken together, we propose that KIF20A plays a critical role in the tumorigenesis and tumor progression of colorectal cancer and could represent a potential therapeutic target for CRC.

American Psychological Association (APA)

Zhang, Qi& Di, Jun& Ji, Zhiyu& Mi, Aoning& Li, Quanying& Du, Xianghui…[et al.]. 2020. KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAKSTAT3 Signaling Pathway. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153773

Modern Language Association (MLA)

Zhang, Qi…[et al.]. KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAKSTAT3 Signaling Pathway. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1153773

American Medical Association (AMA)

Zhang, Qi& Di, Jun& Ji, Zhiyu& Mi, Aoning& Li, Quanying& Du, Xianghui…[et al.]. KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAKSTAT3 Signaling Pathway. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153773

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1153773