Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model
Joint Authors
Sun, Wen
Xu, Guangyuan
Yoshitomi, Hisae
Guo, Xuan
Wu, Lili
Guo, Xiangyu
Qin, Lingling
Fan, Yixin
Xu, Tunhai
Gao, Ming
Liu, Tonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Antiobesity drugs may not be optimal for treating obesity.
However novel antiobesity agents, especially those derived from natural products, may be suitable.
Therefore, we investigated the effects and mechanisms of Cyclocarya paliurus (CP) aqueous extract (CPAE) on obesity.
Methods.
SHR.Cg-Leprcp/NDmcr (SHR/cp) rats were used as a model of obesity and metabolic syndrome.
Experimental animals were allocated into two groups—control and CPAE (0.5 g/kg)—for a 7-week treatment period.
Examinations were performed, including general physiological characteristics, obesity-related biochemical parameters, and insulin-signaling pathway-related proteins in the hypothalamus.
Results.
Treatment with CPAE reduced food intake, body weight, organ weight, fat mass, and body mass index (BMI) in SHR/cp rats.
Meanwhile, CPAE also decreased the levels of fasting serum glucose, fasting serum insulin, HOMA-IR, serum free fatty acids, serum malondialdehyde, serum superoxide dismutase, and serum total-glutathione.
The levels of phosphorylation of target proteins—including InsR, IRS1, PI3Kp85, Akt, and FoXO1 as well as protein expression of POMC—were significantly upregulated in the hypothalamus, but NPY expression remarkably decreased.
Conclusions.
CPAE has antiobesity, antihypoglycemic, antihypolipidemic, and antioxidant properties.
The mechanism responsible for the antiobesity effect of CPAE may be related to suppression of energy intake via regulation of insulin-signaling pathway in the hypothalamus.
American Psychological Association (APA)
Xu, Guangyuan& Yoshitomi, Hisae& Sun, Wen& Guo, Xuan& Wu, Lili& Guo, Xiangyu…[et al.]. 2017. Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153800
Modern Language Association (MLA)
Xu, Guangyuan…[et al.]. Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153800
American Medical Association (AMA)
Xu, Guangyuan& Yoshitomi, Hisae& Sun, Wen& Guo, Xuan& Wu, Lili& Guo, Xiangyu…[et al.]. Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153800