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Plasma Translocator Protein Levels and Outcomes of Acute Ischemic Stroke: A Pilot Study
Joint Authors
Bai, Chyi-Huey
Tsao, Chiung-Wen
Chen, Wen-Hung
Yeh, Hsu-Ling
Lien, Li-Ming
Chiwaya, Arthur
Alizargar, Javad
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Translocator protein 18 kDa (TSPO) has been used as a biomarker of brain injury and inflammation in various neurological diseases.
In this study, we measured the level of TSPO in acute ischemic stroke patients and determined its association with the degree of stroke severity and its ability to predict stroke functional outcomes.
In total, 38 patients with moderate to severe acute ischemic stroke were enrolled.
Demographic information, cerebral risk factors, and stroke severity were examined at the baseline.
The National Institutes of Health Stroke Scale, modified Rankin Scale, and Barthal Index were assessed at discharge as measures of poor functional outcomes and severe disability.
The baseline fasting plasma TSPO level was assessed within 24 h after the incident stroke and during hospitalization (on days 8–10).
The proportion of patients with poor functional outcomes was significantly higher in the higher-TSPO group (compared to the lower group) in terms of clinical worsening (odds ratio (OR) = 11.69, 95% confidence interval (CI) = 2.08–65.6), poor functional outcomes (OR = 10.5, 95% CI = 1.14–96.57), and severe disability (OR = 4.8, 95% CI = 1.20–19.13).
Plasma TSPO may be intimately linked with disease progression and worse functional outcomes in acute ischemic stroke patients.
American Psychological Association (APA)
Chen, Wen-Hung& Yeh, Hsu-Ling& Tsao, Chiung-Wen& Lien, Li-Ming& Chiwaya, Arthur& Alizargar, Javad…[et al.]. 2018. Plasma Translocator Protein Levels and Outcomes of Acute Ischemic Stroke: A Pilot Study. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153801
Modern Language Association (MLA)
Chen, Wen-Hung…[et al.]. Plasma Translocator Protein Levels and Outcomes of Acute Ischemic Stroke: A Pilot Study. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153801
American Medical Association (AMA)
Chen, Wen-Hung& Yeh, Hsu-Ling& Tsao, Chiung-Wen& Lien, Li-Ming& Chiwaya, Arthur& Alizargar, Javad…[et al.]. Plasma Translocator Protein Levels and Outcomes of Acute Ischemic Stroke: A Pilot Study. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153801