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Construction of ceRNA Coexpression Network and Screening of Molecular Targets in Colorectal Cancer
Joint Authors
Jin, Liu
Han, Shuwen
Jing, Zhuang
Xi, Yang
Hui, Zhao
Zhanwei, Wang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To screen some RNAs that correlated with colorectal cancer (CRC).
Methods.
Differentially expressed miRNAs, lncRNAs, and mRNAs between cancer tissues and normal tissues in CRC were identified using data from the Gene Expression Omnibus (GEO) database.
The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and protein-protein interactions (PPIs) were performed to do the functional enrichment analysis.
And a lncRNA-miRNA-mRNA network was constructed which correlated with CRC.
RNAs in this network were subjected to analyze the relationship with the patient prognosis.
Results.
A total of 688, 241, and 103 differentially expressed genes (diff-mRNA), diff-lncRNA, and diff-miRNA were obtained between cancer tissues and normal tissues.
A total of 315 edges were obtained in the ceRNA network.
lncRNA RP11-108K3.2 and mRNA ONECUT2 correlated with prognosis.
Conclusion.
The identified RNAs and constructed ceRNA network could provide great sources for the researches of therapy of the CRC.
And the lncRNA RP11-108K3.2 and mRNA ONECUT2 may serve as a novel prognostic predictor of CRC.
American Psychological Association (APA)
Hui, Zhao& Zhanwei, Wang& Xi, Yang& Jin, Liu& Jing, Zhuang& Han, Shuwen. 2020. Construction of ceRNA Coexpression Network and Screening of Molecular Targets in Colorectal Cancer. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153811
Modern Language Association (MLA)
Hui, Zhao…[et al.]. Construction of ceRNA Coexpression Network and Screening of Molecular Targets in Colorectal Cancer. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153811
American Medical Association (AMA)
Hui, Zhao& Zhanwei, Wang& Xi, Yang& Jin, Liu& Jing, Zhuang& Han, Shuwen. Construction of ceRNA Coexpression Network and Screening of Molecular Targets in Colorectal Cancer. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153811