Low UGP2 Expression Is Associated with Tumour Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma
Joint Authors
Zhu, Weiwei
Yu, Yan
Liu, Liwen
Hu, Qiuyue
Shen, Shen
Zhou, Yongjian
Li, Jianhao
Cui, Guangying
Liu, Xin
Zhang, Yingying
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is a malignant tumour associated with a high mortality rate and poor prognosis worldwide.
Uridine diphosphate-glucose pyrophosphorylase 2 (UGP2), a key enzyme in glycogen biosynthesis, has been reported to be associated with the occurrence and development of various cancer types.
However, its diagnostic value and prognostic value in HCC remain unclear.
The present study observed that UGP2 expression was significantly downregulated at both the mRNA and protein levels in HCC tissues.
Receiver operating characteristic (ROC) curve analysis revealed that UGP2 may be an indicator for the diagnosis of HCC.
In addition, Kaplan-Meier and Cox regression multivariate analyses indicated that UGP2 is an independent prognostic factor of overall survival (OS) in patients with HCC.
Furthermore, gene set enrichment analysis (GSEA) suggested that gene sets negatively correlated with the survival of HCC patients were enriched in the group with low UGP2 expression levels.
More importantly, a significant correlation was identified between low UGP2 expression and fatty acid metabolism.
In summary, the present study demonstrates that UGP2 may contribute to the progression of HCC, indicating a potential therapeutic target for HCC patients.
American Psychological Association (APA)
Hu, Qiuyue& Shen, Shen& Li, Jianhao& Liu, Liwen& Liu, Xin& Zhang, Yingying…[et al.]. 2020. Low UGP2 Expression Is Associated with Tumour Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma. Disease Markers،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153818
Modern Language Association (MLA)
Hu, Qiuyue…[et al.]. Low UGP2 Expression Is Associated with Tumour Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma. Disease Markers No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1153818
American Medical Association (AMA)
Hu, Qiuyue& Shen, Shen& Li, Jianhao& Liu, Liwen& Liu, Xin& Zhang, Yingying…[et al.]. Low UGP2 Expression Is Associated with Tumour Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153818