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Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High-Fat Diet-Fed C57BL6 Mice
Joint Authors
Lee, Byung-Cheol
Kim, Mia
Na, Hyun-Young
Seol, Mi Hyeon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
This study was performed to evaluate the effect of Seyoeum (SYE), a novel herbal meal replacement, on insulin resistance and nonalcoholic fatty liver disease (NAFLD) in obese mice fed with a high-fat diet (HFD).
Methods.
SYE contained six kinds of herbal powder such as Coix lacryma-jobi, Oryza sativa, Sesamum indicum, Glycine max, Liriope platyphylla, and Dioscorea batatas.
Male C57BL/6 mice were divided into four groups: normal chow (NC), HFD, SYE, and HFD plus SYE (HFD + SYE).
The mice in groups other than NC were fed HFD for 9 weeks to induce obesity and then were fed each diet for 6 weeks.
Clinical markers related to obesity, diabetes, and NAFLD were examined and gene expressions related to inflammation and insulin receptor were determined.
Results.
Compared with HFD group, body weight, serum glucose, serum insulin, HOMA-IR, total cholesterol, triglyceride, epididymal fat pad weight, liver weight, and inflammatory gene expression were significantly reduced in SYE group.
Insulin receptor gene expression increased in SYE group.
Conclusions.
Based on these results, we conclude that SYE improved obesity and insulin resistance in high-fat fed obese mice.
Our findings suggest that SYE could be a beneficial meal replacement through these antiobesity and anti-insulin resistance effects.
American Psychological Association (APA)
Na, Hyun-Young& Seol, Mi Hyeon& Kim, Mia& Lee, Byung-Cheol. 2017. Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High-Fat Diet-Fed C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153826
Modern Language Association (MLA)
Na, Hyun-Young…[et al.]. Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High-Fat Diet-Fed C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153826
American Medical Association (AMA)
Na, Hyun-Young& Seol, Mi Hyeon& Kim, Mia& Lee, Byung-Cheol. Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High-Fat Diet-Fed C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153826