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Efficacy and Safety of the Traditional Japanese Medicine Keigairengyoto in the Treatment of Acne Vulgaris
Joint Authors
Ito, Kotaro
Masaki, Saori
Hamada, Manabu
Tokunaga, Tetsuo
Kokuba, Hisashi
Tashiro, Kenji
Yano, Ichiro
Imafuku, Shinichi
Yasumoto, Shinichiro
Source
Dermatology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Several traditional Japanese medicines including Keigairengyoto (KRT) are used to treat acne vulgaris, but there is no robust evidence of their effectiveness.
In this study, we examined the effectiveness and safety of KRT in treating acne vulgaris.
An open-label, randomized, parallel control group comparison was conducted with a conventional treatment group (adapalene and topical antibiotics; control group) and a KRT group (control treatment plus KRT).
The test drugs were administered for 12 weeks to patients (15 to 64 years, outpatient) with inflammatory acne on their face, and the amount of acne at 2, 4, 8, and 12 weeks was measured.
Sixty-four patients were enrolled; 29 patients in each group were included in the analysis.
Twenty-eight patients in the control group and 24 patients in the KRT group were included in the efficacy analysis.
The number of inflammatory skin rashes at 4 and 8 weeks in the KRT group was significantly decreased compared with the control group.
There was no significant difference between the two groups in noninflammatory eruptions and general rashes.
There were no serious adverse events in both groups.
KRT may be a useful agent in patients with inflammatory acne in combination with conventional treatments.
This trial is registered with UMIN 000014831.
American Psychological Association (APA)
Ito, Kotaro& Masaki, Saori& Hamada, Manabu& Tokunaga, Tetsuo& Kokuba, Hisashi& Tashiro, Kenji…[et al.]. 2018. Efficacy and Safety of the Traditional Japanese Medicine Keigairengyoto in the Treatment of Acne Vulgaris. Dermatology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153858
Modern Language Association (MLA)
Ito, Kotaro…[et al.]. Efficacy and Safety of the Traditional Japanese Medicine Keigairengyoto in the Treatment of Acne Vulgaris. Dermatology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153858
American Medical Association (AMA)
Ito, Kotaro& Masaki, Saori& Hamada, Manabu& Tokunaga, Tetsuo& Kokuba, Hisashi& Tashiro, Kenji…[et al.]. Efficacy and Safety of the Traditional Japanese Medicine Keigairengyoto in the Treatment of Acne Vulgaris. Dermatology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153858