An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism
Joint Authors
Paul-Samojedny, Monika
Suchanek-Raif, Renata
Raif, Paweł
Zielińska, Aleksandra
Kucia, Krzysztof
Merk, Wojciech
Kowalski, Jan
Kowalczyk, Małgorzata
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
The BDNF dysfunction in the schizophrenia has been soundly documented.
The TrkB gene is a high-affinity receptor of the BDNF that is changed in schizophrenia and mood disorders.
The study had two aims: first, to identify whether the five nucleotide polymorphisms (SNPs) in TrkB gene are associated with a diagnosis of schizophrenia; and the latter, if any association exists between the TrkB SNPs and psychopathology, suicide attempts, and family history of schizophrenia in a Caucasian population.
Methods.
Case-control study (401 patients and 657 healthy controls) was used to examine a predisposition for schizophrenia.
The tests for psychopathology, suicide attempts, and family history of schizophrenia were conducted only in patient group.
The severity of the schizophrenia was measured using the five-factor model of the PANSS.
In addition, the haplotype analysis for both the separate for SNPs of TrkB gene and in combination with the rs6265 SNP BDNF gene was conducted.
Results.
Our case-control study revealed that the genetic variants of rs10868235 (T/T polymorphic genotype) and rs1387923 (G/G polymorphic genotype) of the TrkB gene were associated with a higher risk of developing schizophrenia in men.
However, the A/A wild genotype of rs1387923 was connected with a lower risk for both the development of and the family manifestation of schizophrenia in men.
The G polymorphic allele of rs1565445 was associated with an increased risk of suicide in schizophrenia.
The tested SNPs of the TrkB gene did not modulate the psychopathology of schizophrenia.
The haplotype that was built with five SNPs in the TrkB gene was protective for men, but after joining the rs6265 SNP of the BDNF gene, a haplotype that was protective for women was created.
American Psychological Association (APA)
Suchanek-Raif, Renata& Raif, Paweł& Kowalczyk, Małgorzata& Paul-Samojedny, Monika& Zielińska, Aleksandra& Kucia, Krzysztof…[et al.]. 2020. An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism. Disease Markers،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153861
Modern Language Association (MLA)
Suchanek-Raif, Renata…[et al.]. An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism. Disease Markers No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1153861
American Medical Association (AMA)
Suchanek-Raif, Renata& Raif, Paweł& Kowalczyk, Małgorzata& Paul-Samojedny, Monika& Zielińska, Aleksandra& Kucia, Krzysztof…[et al.]. An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153861