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Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study
Joint Authors
Peng, Liang
Wang, Hao
Lai, Liying
Lai, Yijie
Zhou, Ning
Tian, Yi
Jiang, Yongfang
Gong, Guozhong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
Gram-negative bloodstream infections (GNBSIs), especially those caused by antibiotic-resistant species, have become a public health challenge.
Procalcitonin (PCT) showed promising potential in early diagnosis of GNBSI; however, little was known about its performance under different clinical settings.
We here systematically assessed the diagnostic accuracy of PCT in recognizing GNBSI and made direct comparisons with C-reactive protein (CRP) and interleukin 6 (IL-6).
Methods.
PubMed, Embase, ISI Web of Knowledge, and Scopus were searched from inception to March 15th, 2019.
Area under the summary receiver operating characteristic curve (AUC), pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated.
Hierarchical summary receiver operating characteristic (HSROC) model was used for the investigation of heterogeneity and for comparisons between markers.
Results.
25 studies incorporating 50933 suspected BSI episodes were included.
Pooled sensitivity and specificity for PCT were 0.71 and 0.76, respectively.
The overall AUC was 0.80.
The lowest AUCs were found in patients with febrile neutropenia (0.69) and hematological malignancy (0.69).
The highest AUC was found in groups using electrochemiluminescence immunoassay (0.87).
In direct comparisons, PCT showed better overall performance than CRP with the AUC being 0.85 (95% CI 0.81–0.87) for PCT and 0.78 (95% CI 0.74–0.81) for CRP, but the relative DORs varied with thresholds between PCT and CRP (p<0.001).
No significant difference was found either in threshold (p=0.654) or in accuracy (p=0.480) between PCT and IL-6 in diagnosing GNBSI.
Conclusions.
PCT was helpful in recognizing GNBSI, but the test results should be interpreted carefully with knowledge of patients’ medical condition and should not serve as the only criterion for GNBSI.
Further prospective studies are warranted for comparisons between different clinical settings.
American Psychological Association (APA)
Lai, Liying& Lai, Yijie& Wang, Hao& Peng, Liang& Zhou, Ning& Tian, Yi…[et al.]. 2020. Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study. Disease Markers،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1153865
Modern Language Association (MLA)
Lai, Liying…[et al.]. Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study. Disease Markers No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1153865
American Medical Association (AMA)
Lai, Liying& Lai, Yijie& Wang, Hao& Peng, Liang& Zhou, Ning& Tian, Yi…[et al.]. Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1153865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153865