Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model
Joint Authors
Chen, Ning-Yuan
Liu, Cheng-Wu
Lin, Wei
Ding, Yi
Bian, Zhang-ya
Huang, Ling
Huang, Hao
Yu, Kai-Hui
Chen, Si-Bang
Sun, Yu
Wei, Lei
Peng, Jun-Hua
Pan, Shang-Ling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hempseed (Cannabis sativa L.) has been used as a health food and folk medicine in China for centuries.
In the present study, we sought to define the underlying mechanism by which the extract of Fructus Cannabis (EFC) protects against memory impairment induced by D-galactose in rats.
To accelerate aging and induce memory impairment in rats, D-galactose (400 mg/kg) was injected intraperitoneally once daily for 14 weeks.
EFC (200 and 400 mg/kg) was simultaneously administered intragastrically once daily in an attempt to slow the aging process.
We found that EFC significantly increased the activity of superoxide dismutase, while lowering levels of malondialdehyde in the hippocampus.
Moreover, EFC dramatically elevated the organ indices of some organs, including the heart, the liver, the thymus, and the spleen.
In addition, EFC improved the behavioral performance of rats treated with D-galactose in the Morris water maze.
Furthermore, EFC inhibited the activation of astrocytes and remarkably attenuated phosphorylated tau and suppressed the expression of presenilin 1 in the brain of D-galactose-treated rats.
These findings suggested that EFC exhibits beneficial effects on the cognition of aging rats probably by enhancing antioxidant capacity and anti-neuroinflammation, improving immune function, and modulating tau phosphorylation and presenilin expression.
American Psychological Association (APA)
Chen, Ning-Yuan& Liu, Cheng-Wu& Lin, Wei& Ding, Yi& Bian, Zhang-ya& Huang, Ling…[et al.]. 2017. Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153875
Modern Language Association (MLA)
Chen, Ning-Yuan…[et al.]. Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153875
American Medical Association (AMA)
Chen, Ning-Yuan& Liu, Cheng-Wu& Lin, Wei& Ding, Yi& Bian, Zhang-ya& Huang, Ling…[et al.]. Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153875