Assessing the Prognostic Performance of the Child-Pugh, Model for End-Stage Liver Disease, and Albumin-Bilirubin Scores in Patients with Decompensated Cirrhosis: A Large Asian Cohort from Gastroenterology Department
Joint Authors
Wan, Si-Zhe
Nie, Yuan
Zhang, Yue
Liu, Cong
Zhu, Xuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Aim.
Various methods, including the Child-Pugh score, the model for end-stage liver disease (MELD) score, the MELD combined with serum sodium concentration (MELD-Na) score, the integrated MELD (iMELD) score, and the albumin-bilirubin (ALBI) score, have been widely used for predicting the survival of decompensated cirrhosis (DeCi) patients.
In this study, we defined and compared the prognostic value of these scores to predict mortality in DeCi patients.
Methods.
We performed a single-center, observational retrospective study and analyzed 456 DeCi patients who were hospitalized in the gastroenterology department.
The biochemical examination results and demographic characteristics of the patients were obtained, and five scores were calculated upon admission after 24 hours.
All patients were observed until death, loss to follow-up, or specific follow-up times (28 days, 90 days, and 6 months).
A receiver operating characteristic (ROC) curve was used to evaluate the ability of these methods to predict mortality in DeCi patients.
Results.
At 28 days, 90 days, and 6 months, the cumulative number of deaths was 50 (11.0%), 76 (16.6%), and 91 (19.9%), respectively.
The scores were significantly higher in nonsurviving patients than in surviving patients.
All scores yielded viable values in predicting 28-day, 90-day, and 6-month prognoses for DeCi patients.
The areas under the ROC curve (AUROCs) of the ALBI score were higher than those of the other scores, which were only over 0.700 at 28 days.
The AUROC of the MELD score was higher than that of the other scores, including the MELD-Na and iMELD scores, at 90 days and 6 months.
Conclusion.
All five methods (Child-Pugh score, MELD score, MELD-Na score, iMELD score, and ALBI score) provided a reliable prediction of mortality for both the short-term and long-term prognosis of patients with DeCi.
The ALBI score may be particularly useful for assessing short-term outcomes, whereas the MELD score may be particularly useful for assessing long-term outcomes.
American Psychological Association (APA)
Wan, Si-Zhe& Nie, Yuan& Zhang, Yue& Liu, Cong& Zhu, Xuan. 2020. Assessing the Prognostic Performance of the Child-Pugh, Model for End-Stage Liver Disease, and Albumin-Bilirubin Scores in Patients with Decompensated Cirrhosis: A Large Asian Cohort from Gastroenterology Department. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153877
Modern Language Association (MLA)
Wan, Si-Zhe…[et al.]. Assessing the Prognostic Performance of the Child-Pugh, Model for End-Stage Liver Disease, and Albumin-Bilirubin Scores in Patients with Decompensated Cirrhosis: A Large Asian Cohort from Gastroenterology Department. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153877
American Medical Association (AMA)
Wan, Si-Zhe& Nie, Yuan& Zhang, Yue& Liu, Cong& Zhu, Xuan. Assessing the Prognostic Performance of the Child-Pugh, Model for End-Stage Liver Disease, and Albumin-Bilirubin Scores in Patients with Decompensated Cirrhosis: A Large Asian Cohort from Gastroenterology Department. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153877