Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis
Joint Authors
Sun, Chao
Wu, Bin
Pan, Jiang
Chen, Lulu
Zhi, Wenxian
Tang, Ruze
Zhao, Dongliang
Guo, Wanliang
Huang, Shungen
Wang, Jian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA).
However, results regarding its diagnostic accuracy are inconsistent and inconclusive.
We conducted this meta-analysis with an aim to systematically evaluate the diagnostic value of HSF in predicting BA.
Methods.
A comprehensive literature search of four databases was conducted to identify the eligible studies.
All analyses were performed using STATA 12.0.
Results.
Nine studies from eight articles containing 368 patients and 469 controls were included in our meta-analysis.
Briefly, the values for pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.95 (95% CI 0.88-0.98), 0.92 (95% CI 0.85-0.96), 11.6 (95% CI 6.3-21.5), 0.06 (95% CI 0.02-0.14), 201 (95% CI 59-689), and 0.98 (95% CI 0.96-0.99), respectively.
Additionally, metaregression along with subgroup analysis based on various covariates revealed the potential sources of heterogeneity and the detailed diagnostic value in each subgroup.
Conclusion.
Our meta-analysis showed that HSF assay could provide high accuracy in predicting BA patients and non-BA individuals.
However, further studies with better design and larger sample size are required to support the results of the present study.
American Psychological Association (APA)
Sun, Chao& Wu, Bin& Pan, Jiang& Chen, Lulu& Zhi, Wenxian& Tang, Ruze…[et al.]. 2020. Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153878
Modern Language Association (MLA)
Sun, Chao…[et al.]. Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153878
American Medical Association (AMA)
Sun, Chao& Wu, Bin& Pan, Jiang& Chen, Lulu& Zhi, Wenxian& Tang, Ruze…[et al.]. Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153878