Confocal Microscopy Predicts the Risk of Recurrence and Malignant Transformation of Mucocutaneous Neurofibromas in NF-1: An Observational Study
Joint Authors
Vestita, Michelangelo
Limongelli, Luisa
Tempesta, Angela
Giudice, Giuseppe
Favia, Giorgio
Source
Dermatology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
From 2005 to 2010, 20 consecutive patients with fully manifested neurofibromatosis type 1 (NF1) underwent elective neurofibroma resection at our institution (Departments of Plastic Surgery and of Odontostomatology).
Specimens were photographed under optical microscope and confocal laser scanning microscopy (CLSM) with ultra-high accuracy of detail, including depth of field.
Patients were followed up for a minimum of 4 years and up to a maximum of 12 years, postsurgery.
While all nonrecurring lesions showed intense fluorescence, six of the seven lesions with absence of fluorescence under CLSM recurred at a mean of 5.5 years after surgical excision.
Among the re-excised lesions, 3 were diagnosed as malignant at the subsequent removal.
Despite the limitation of a small cohort, CLSM appears to be a simple and low-cost technique to differentiate forms of neurofibromas with low and high risk of recurrence and malignant degeneration.
American Psychological Association (APA)
Giudice, Giuseppe& Favia, Giorgio& Tempesta, Angela& Limongelli, Luisa& Vestita, Michelangelo. 2018. Confocal Microscopy Predicts the Risk of Recurrence and Malignant Transformation of Mucocutaneous Neurofibromas in NF-1: An Observational Study. Dermatology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153889
Modern Language Association (MLA)
Giudice, Giuseppe…[et al.]. Confocal Microscopy Predicts the Risk of Recurrence and Malignant Transformation of Mucocutaneous Neurofibromas in NF-1: An Observational Study. Dermatology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1153889
American Medical Association (AMA)
Giudice, Giuseppe& Favia, Giorgio& Tempesta, Angela& Limongelli, Luisa& Vestita, Michelangelo. Confocal Microscopy Predicts the Risk of Recurrence and Malignant Transformation of Mucocutaneous Neurofibromas in NF-1: An Observational Study. Dermatology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153889