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Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?
Joint Authors
Source
Dermatology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Acne vulgaris is an inflammatory disease of pilosebaceous units which may cause permanent dyspigmentation and/or scars if not treated.
Isotretinoin is recommended in the treatment of recalcitrant or severe acne, but it is associated with common adverse effects that frequently result in patients incompliance and discontinuation of the drug.
The present study was designed to assess the efficacy of oral omega-3 in decreasing the adverse effects of isotretinoin.
Materials and Methods.
In this randomized double-blind clinical trial, a total of 118 patients with moderate or severe acne were randomly divided into two (case and control) groups.
The control group was treated with isotretinoin 0.5 mg/kg, and the case group was treated with the same dose of isotretinoin combined with oral omega-3 (1 g/day).
The treatment was lasted for 16 weeks and mucocutaneous side effects of isotretinoin were recorded and compared between the two groups in weeks 4, 8, 12, and 16.
Results.
Cheilitis (at weeks 4, 8, and 12), xerosis, dryness of nose at all weeks, and dryness of eyes (at week 4) were less frequent in the group that received isotretinoin combined with oral omega-3 compared to the group that received isotretinoin alone.
Conclusion.
Administration of oral omega-3 in acne patients who are receiving isotretinoin decreases the mucocutaneous side effects of isotretinoin.
This trial is registered with IRCT201306238241N2.
American Psychological Association (APA)
Mirnezami, Mina& Rahimi, Hoda. 2018. Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?. Dermatology Research and Practice،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1153901
Modern Language Association (MLA)
Mirnezami, Mina& Rahimi, Hoda. Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?. Dermatology Research and Practice No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1153901
American Medical Association (AMA)
Mirnezami, Mina& Rahimi, Hoda. Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?. Dermatology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1153901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153901