Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3KAktmTOR Signaling Pathway in HER2+ Breast Cancer
Joint Authors
Ji, Hongfei
Yin, Lei
Zhang, Fengxia
Wang, Yiran
Zhang, Han
Wang, Jinlu
Niu, Xingjian
Gu, Yucui
Li, Dongbo
Lu, Minghui
Zhang, Qingyuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aerobic glycolysis is a hallmark of tumor cells.
SGLT1 plays a vital role in glucose metabolism.
However, whether SGLT1 could promote cell growth and proliferation in breast cancer remains unclear.
Here, we investigated the expression of SGLT1 in breast cancer and examined its role in malignant behavior and prognosis.
Further, we examined the SGLT1 expression in breast cancer tissues and its relationship with clinicopathologic characteristics.
We clarified that SGLT1 was overexpressed in HER2+ breast cancer cell lines and was affected by HER2 status.
We further found that SGLT1 affected breast cancer cell proliferation and patient survival by mediating cell survival pathway activation.
SGLT1 was overexpressed in HER2+ breast cancers and associated with lymph node metastasis and HER2+ status.
Inhibition of HER2 decreased SGLT1 expression, and the extracellular acidification rate was also reduced in the UACC812 and SKBR3 cell lines.
These changes could be reversed by proteasome inhibitor treatment.
Knockdown of SGLT1 blocked PI3K/Akt/mTOR signaling, thereby inhibiting cell proliferation.
Further, we demonstrated that high SGLT1 was significantly correlated with shorter survival in all breast cancer patients and specifically in HER2+ breast cancer patients.
Therefore, we conclude that SGLT1 is overexpressed in HER2+ breast cancer, thereby promoting cell proliferation and shortening survival by activating PI3K/Akt/mTOR signaling.
This study submits that SGLT1 is promising not only as a novel biomarker of HER2+ breast cancer subtype but also as a potential drug target.
American Psychological Association (APA)
Wang, Jinlu& Ji, Hongfei& Niu, Xingjian& Yin, Lei& Wang, Yiran& Gu, Yucui…[et al.]. 2020. Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3KAktmTOR Signaling Pathway in HER2+ Breast Cancer. Disease Markers،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1153916
Modern Language Association (MLA)
Wang, Jinlu…[et al.]. Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3KAktmTOR Signaling Pathway in HER2+ Breast Cancer. Disease Markers No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1153916
American Medical Association (AMA)
Wang, Jinlu& Ji, Hongfei& Niu, Xingjian& Yin, Lei& Wang, Yiran& Gu, Yucui…[et al.]. Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3KAktmTOR Signaling Pathway in HER2+ Breast Cancer. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1153916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153916