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Clinical Characteristics of Colorectal Cancer Patients in terms of Selected Platelet Indices
Joint Authors
Nowakowska-Zajdel, Ewa
Copija, Angelika
Janion, Karolina
Walkiewicz, Katarzyna
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mounting evidence suggests that inflammation, immune response, and coagulation status determine many processes during the carcinogenesis pathway in colorectal cancer (CRC).
Inflammation strongly promotes tumor formation, progression, and metastasis.
The systemic inflammatory response (SIR) may be reflected by simple indicators evaluated on the basis of peripheral blood morphology parameters.
The indices are easily obtained by the peripheral blood test and could be promising biomarkers for CRC.
We present the results of the retrospective study evaluating the potential relation between the platelet indices (platelet count (PC), platelet-to-lymphocyte ratio (PLR), neutrophil platelet score (NPS), mean platelet volume (MPV), and MPV/PC ratio) and the clinicopathological features of CRC patients.
The study included 247 patients (104 males and 143 females) aged 39-87 years with CRC stages II-IV.
The complete blood counts with the automated differential counts were performed prior to the qualification to systemic treatment.
High PC, high PLR, and NPS 0 were associated with older age and higher BMI of the patients.
No link between the analyzed platelet indices and histological grade of the tumor, primary tumor location, and gender was noted.
The patients aged ≥65 years were characterized by the higher MPV/PC ratio than the younger population.
We observed a trend to the higher MPV/PC ratio among the patients with excessive body weight defined by BMI compared to BMI within normal limits.
A higher frequency of PC>400, NPS 1 and 2, and a trend to more frequent PLR≥150 were observed in the subgroup with metastatic disease compared to individuals with CRC stages II and III.
The presented results expand the knowledge on potential association between SIR parameters and other clinicopathological factors that should be considered during interpreting the prognostic and predictive value of the inflammation parameters.
American Psychological Association (APA)
Copija, Angelika& Nowakowska-Zajdel, Ewa& Janion, Karolina& Walkiewicz, Katarzyna. 2020. Clinical Characteristics of Colorectal Cancer Patients in terms of Selected Platelet Indices. Disease Markers،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153920
Modern Language Association (MLA)
Copija, Angelika…[et al.]. Clinical Characteristics of Colorectal Cancer Patients in terms of Selected Platelet Indices. Disease Markers No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1153920
American Medical Association (AMA)
Copija, Angelika& Nowakowska-Zajdel, Ewa& Janion, Karolina& Walkiewicz, Katarzyna. Clinical Characteristics of Colorectal Cancer Patients in terms of Selected Platelet Indices. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153920