Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation

Joint Authors

Bjerre, Anna
Thorsteinsdottir, Hjordis
Salvador, Cathrin Lytomt
Mjøen, Geir
Lie, Anine
Sugulle, Meryam
Tøndel, Camilla
Brun, Atle
Almaas, Runar

Source

Disease Markers

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-02-06

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Growth differentiation factor 15 (GDF-15) is strongly associated with cardiovascular disease (CVD).

The aim of our study was to evaluate plasma and urinary levels of GDF-15 after pediatric renal transplantation (Rtx) and in children with chronic kidney disease (CKD) and its associations to cardiovascular risk factors.

In this cross-sectional study, GDF-15 was measured in plasma and urine from 53 children with a renal transplant and 83 children with CKD and related to cardiovascular risk factors (hypertension, obesity, and cholesterol) and kidney function.

Forty healthy children served as a control group.

Plasma levels of GDF-15 (median and range) for a Tx (transplantation) cohort, CKD cohort, and healthy controls were, respectively, 865 ng/L (463-3039 ng/L), 508 ng/L (183-3279 ng/L), and 390 ng/L (306-657 ng/L).

The CKD and Tx cohorts both had significantly higher GDF-15 levels than the control group (p<0.001).

Univariate associations between GDF-15 and hyperuricemia (p<0.001), elevated triglycerides (p=0.028), low HDL (p=0.038), and obesity (p=0.028) were found.

However, mGFR (p<0.001) and hemoglobin (p<0.001) were the only significant predictors of GDF-15 in an adjusted analysis.

Urinary GDF-15/creatinine ratios were 448 ng/mmol (74–5013 ng/mmol) and 540 ng/mmol (5–14960 ng/mmol) in the Tx cohort and CKD cohort, respectively.

In the CKD cohort, it was weakly correlated to mGFR (r=−0.343, p=0.002).

Plasma levels of GDF-15 are elevated in children with CKD and after Rtx.

The levels were not associated with traditional cardiovascular risk factors but strongly associated with renal function.

American Psychological Association (APA)

Thorsteinsdottir, Hjordis& Salvador, Cathrin Lytomt& Mjøen, Geir& Lie, Anine& Sugulle, Meryam& Tøndel, Camilla…[et al.]. 2020. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153923

Modern Language Association (MLA)

Thorsteinsdottir, Hjordis…[et al.]. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153923

American Medical Association (AMA)

Thorsteinsdottir, Hjordis& Salvador, Cathrin Lytomt& Mjøen, Geir& Lie, Anine& Sugulle, Meryam& Tøndel, Camilla…[et al.]. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153923

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1153923