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Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation
Joint Authors
Bjerre, Anna
Thorsteinsdottir, Hjordis
Salvador, Cathrin Lytomt
Mjøen, Geir
Lie, Anine
Sugulle, Meryam
Tøndel, Camilla
Brun, Atle
Almaas, Runar
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Growth differentiation factor 15 (GDF-15) is strongly associated with cardiovascular disease (CVD).
The aim of our study was to evaluate plasma and urinary levels of GDF-15 after pediatric renal transplantation (Rtx) and in children with chronic kidney disease (CKD) and its associations to cardiovascular risk factors.
In this cross-sectional study, GDF-15 was measured in plasma and urine from 53 children with a renal transplant and 83 children with CKD and related to cardiovascular risk factors (hypertension, obesity, and cholesterol) and kidney function.
Forty healthy children served as a control group.
Plasma levels of GDF-15 (median and range) for a Tx (transplantation) cohort, CKD cohort, and healthy controls were, respectively, 865 ng/L (463-3039 ng/L), 508 ng/L (183-3279 ng/L), and 390 ng/L (306-657 ng/L).
The CKD and Tx cohorts both had significantly higher GDF-15 levels than the control group (p<0.001).
Univariate associations between GDF-15 and hyperuricemia (p<0.001), elevated triglycerides (p=0.028), low HDL (p=0.038), and obesity (p=0.028) were found.
However, mGFR (p<0.001) and hemoglobin (p<0.001) were the only significant predictors of GDF-15 in an adjusted analysis.
Urinary GDF-15/creatinine ratios were 448 ng/mmol (74–5013 ng/mmol) and 540 ng/mmol (5–14960 ng/mmol) in the Tx cohort and CKD cohort, respectively.
In the CKD cohort, it was weakly correlated to mGFR (r=−0.343, p=0.002).
Plasma levels of GDF-15 are elevated in children with CKD and after Rtx.
The levels were not associated with traditional cardiovascular risk factors but strongly associated with renal function.
American Psychological Association (APA)
Thorsteinsdottir, Hjordis& Salvador, Cathrin Lytomt& Mjøen, Geir& Lie, Anine& Sugulle, Meryam& Tøndel, Camilla…[et al.]. 2020. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153923
Modern Language Association (MLA)
Thorsteinsdottir, Hjordis…[et al.]. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153923
American Medical Association (AMA)
Thorsteinsdottir, Hjordis& Salvador, Cathrin Lytomt& Mjøen, Geir& Lie, Anine& Sugulle, Meryam& Tøndel, Camilla…[et al.]. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153923