![](/images/graphics-bg.png)
Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes
Joint Authors
Bharti, Praveen Kumar
Singh, Puspendra P.
Bhandari, Sneha
Sharma, Ravendra K.
Singh, Neeru
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Malaria in pregnancy causes adverse birth outcomes due to sequestration of Plasmodium falciparum-infected erythrocytes in the placenta.
Angiopoietins are critical regulators of vascular development and formation of placental villous vasculature.
Angiopoietin-1 and Angiopoietin-2 concentrations were measured in peripheral and placental plasma samples from 70 malaria-infected and 216 control women using commercially available DuoSet ELISA development kit.
Angiopoietins increased in placental plasma (ANG1-5833.5 pg/ml and ANG2-9580.6 pg/ml) as compared to peripheral plasma (ANG1-2293.1 pg/ml and ANG2-1198.9 pg/ml, p<0.0001).
The concentration of placental and peripheral ANG1 (6099.23 pg/ml and 2320.5 pg/ml) was significantly lower (5013.5 pg/ml, 2208.5 pg/ml), and ANG2 (9553.3 pg/ml, 1180.92 pg/ml) was significantly higher (9664.6 pg/ml, 1254.4 pg/ml) in malaria-positive cases as compared to malaria-negative (p<0.0001).
The association of dysregulated angiopoietins in malaria with adverse birth outcomes showed that the peripheral and placental ANG1 concentration was lower and ANG2 concentration was higher in low-birth-weight baby and stillbirth birth outcome as compared to normal deliveries among malaria-positive group.
Therefore, ANG1 and ANG2 could be considered a biomarker for adverse outcome during malaria in pregnancy.
American Psychological Association (APA)
Singh, Puspendra P.& Bhandari, Sneha& Sharma, Ravendra K.& Singh, Neeru& Bharti, Praveen Kumar. 2020. Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153926
Modern Language Association (MLA)
Singh, Puspendra P.…[et al.]. Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153926
American Medical Association (AMA)
Singh, Puspendra P.& Bhandari, Sneha& Sharma, Ravendra K.& Singh, Neeru& Bharti, Praveen Kumar. Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153926