Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC
Joint Authors
Serria, Hammami Turky
Sahnoun, Zouheir
Ksouda Moalla, Kamilia
Ben Salem, Maryem
Dhouibi, Raouia
Zeghal, Khaled Mounir
Affes, Hanen
Athmouni, Khaled
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
Artichoke (Cynara scolymus L.) was one of the plant remedies for primary health care.
The present study was focused on the determination of chemical composition, antioxidant activities, and anti-inflammatory activity and on analyzing its major bioactive polyphenols by HPLC.
Methods.
Artichoke Leaves Extracts (ALE) were analyzed for proximate analysis and phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test.
The carrageenan (Carr) model induced paw oedema in order to investigate the anti-inflammatory activity.
Identification and quantification of bioactive polyphenols compounds were done by HPLC method.
The oxidative stress parameters were determined; CAT, SOD, GSH, MDA, and AOPP activities and the histopathological examination were also performed.
Results.
It was noted that EtOH extract of ALE contained the highest phenolic, flavonoid, and tannin contents and the strongest antioxidants activities including DDPH (94.23%), ABTS (538.75 mmol), FRAP assay (542.62 umol), and β-carotene bleaching (70.74%) compared to the other extracts of ALE.
Administration of EtOH extract at dose 400 mg/kg/bw exhibited a maximum inhibition of inflammation induced by Carr for 3 and 5 hours compared to reference group Indomethacin (Indo).
Conclusion.
ALE displayed high potential as natural source of minerals and phytochemicals compounds with antioxidant and anti-inflammatory properties.
American Psychological Association (APA)
Ben Salem, Maryem& Affes, Hanen& Athmouni, Khaled& Ksouda Moalla, Kamilia& Dhouibi, Raouia& Sahnoun, Zouheir…[et al.]. 2017. Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1153932
Modern Language Association (MLA)
Ben Salem, Maryem…[et al.]. Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1153932
American Medical Association (AMA)
Ben Salem, Maryem& Affes, Hanen& Athmouni, Khaled& Ksouda Moalla, Kamilia& Dhouibi, Raouia& Sahnoun, Zouheir…[et al.]. Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1153932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153932