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Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study
Joint Authors
Rahimi, Hoda
Tehranchinia, Zohreh
Saghi, Bita
Source
Dermatology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin.
Tranexamic acid (TA) can reduce melanin content of epidermis.
Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid local infiltration in combination with topical 4% hydroquinone cream compared to topical 4% hydroquinone cream alone in patients with melasma.
Material and Methods.
This study was a prospective assessor- and analyst-blind, randomized split-face clinical trial which was performed on patients with bilateral malar epidermal melasma.
A total of 55 patients were enrolled, and each side of their face was randomly allocated to either TA+HQ or HQ alone treatment.
The MASI score was applied as an objective measurement to compare two treatment groups.
The patient's satisfaction of melasma treatment was evaluated using a four-scale grading, as well.
Results.
The mean of MASI score in week 16 decreased in both groups significantly (p < 0.01).
The therapeutic outcomes were significantly better in TA+HQ group than HQ group (p=0.001).
Patients satisfaction with treatment was significantly higher in the TA + HQ group.
The difference between the two groups regarding side effect occurrence was not statistically significant.
Conclusion.
Addition of tranexamic acid injections to conventional hydroquinone therapy can increase the efficacy of topical treatment.
This trial is registered with IRCT2015110324865N1.
American Psychological Association (APA)
Tehranchinia, Zohreh& Saghi, Bita& Rahimi, Hoda. 2018. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study. Dermatology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153933
Modern Language Association (MLA)
Tehranchinia, Zohreh…[et al.]. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study. Dermatology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1153933
American Medical Association (AMA)
Tehranchinia, Zohreh& Saghi, Bita& Rahimi, Hoda. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study. Dermatology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153933