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Jinhong Tablet Reduces Damage of Intestinal Mucosal Barrier in Rats with Acute Biliary Infection via Bcl-2Bax mRNA and Protein Regulation
Joint Authors
Liang, Xiaoqiang
Ni, Xiao
Wang, YongQi
Xie, Jinkun
Zhang, Xuelin
Gu, Honggang
Zhang, Jingzhe
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To explore the effects and mechanism of Jinhong Tablet on intestinal mucosal barrier function and SIRS in rats with acute biliary infection.
Methods.
36 SD male rats were divided into three groups: sham operation (control), acute biliary infection (ABI) model, and Jinhong Tablet (Jinhong) group.
Jinhong group were force-fed with Jinhong Tablet, while the other two groups received oral saline.
At days 3 and 5, morphological changes of intestinal mucosa were assessed.
Serum diamine oxidase (DAO), D-lactate, and endotoxin levels were measured.
And the genes bcl-2 and bax in intestinal tissues were tested by real-time PCR and Western blotting.
Results.
Intestinal damage was significantly less severe in Jinhong group compared with ABI group, as indicated by Chiu’s scoring, TUNEL analysis, and serum DAO, D-lactic acid, and endotoxin levels.
Additionally, the expression of bax mRNA and protein was decreased and the ratio of bcl-2/bax mRNA and protein was increased compared with ABI group.
Conclusion.
Jinhong Tablet had a positive intervention on acute biliary infection through improving inflammation and intestinal mucosal barrier, inhibiting excessive apoptosis of intestinal epithelial cells via bax and bcl-2 gene, and protein regulation.
American Psychological Association (APA)
Liang, Xiaoqiang& Ni, Xiao& Wang, YongQi& Xie, Jinkun& Zhang, Xuelin& Gu, Honggang…[et al.]. 2017. Jinhong Tablet Reduces Damage of Intestinal Mucosal Barrier in Rats with Acute Biliary Infection via Bcl-2Bax mRNA and Protein Regulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153937
Modern Language Association (MLA)
Liang, Xiaoqiang…[et al.]. Jinhong Tablet Reduces Damage of Intestinal Mucosal Barrier in Rats with Acute Biliary Infection via Bcl-2Bax mRNA and Protein Regulation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153937
American Medical Association (AMA)
Liang, Xiaoqiang& Ni, Xiao& Wang, YongQi& Xie, Jinkun& Zhang, Xuelin& Gu, Honggang…[et al.]. Jinhong Tablet Reduces Damage of Intestinal Mucosal Barrier in Rats with Acute Biliary Infection via Bcl-2Bax mRNA and Protein Regulation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153937