Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
Joint Authors
Yuan, Ning
Sun, Peng
Feng, Xiaodong
Song, Guanghui
Sun, Zhenqing
Lun, Limin
Wang, Lu
Wang, Qing
Zhang, Zhijun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine.
The present study was designed to investigate the expression and function of IL-18 in colon cancer.
In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients.
This decreased expression of IL-18 was significantly correlated with the tumor size (P=0.001) and American Joint Committee on Cancer (AJCC) stage (P=0.013).
Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors.
Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation.
Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation.
IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients.
American Psychological Association (APA)
Feng, Xiaodong& Zhang, Zhijun& Sun, Peng& Song, Guanghui& Wang, Lu& Sun, Zhenqing…[et al.]. 2020. Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153944
Modern Language Association (MLA)
Feng, Xiaodong…[et al.]. Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153944
American Medical Association (AMA)
Feng, Xiaodong& Zhang, Zhijun& Sun, Peng& Song, Guanghui& Wang, Lu& Sun, Zhenqing…[et al.]. Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153944
