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Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro
Joint Authors
Ratnasooriya, W. D.
Abeysekera, Walimuni Prabhashini Kaushalya Mendis
Arachchige, Sirimal Premakumara Galbada
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ethanol (95%) and dichloromethane : methanol (DCM : M, 1 : 1 v/v) bark extracts (BEs) and leaf extracts (LEs) of authenticated Ceylon cinnamon (CC) were studied for antiamylase, antiglucosidase, anticholinesterases, and antiglycation and glycation reversing potential in bovine serum albumin- (BSA-) glucose and BSA-methylglyoxal models in vitro.
Further, total proanthocyanidins (TP) were quantified.
Results showed significant differences (p<0.05) between bark and leaf extracts for the studied biological activities (except antiglucosidase) and TP.
BEs showed significantly high (p<0.05) activities for antiamylase (IC50: 214±2–215±10 μg/mL), antibutyrylcholinesterase (IC50: 26.62±1.66–36.09±0.83 μg/mL), and glycation reversing in BSA-glucose model (EC50: 94.33±1.81–107.16±3.95 μg/mL) compared to LEs.
In contrast, glycation reversing in BSA-methylglyoxal (EC50: ethanol: 122.15±6.01 μg/mL) and antiglycation in both BSA-glucose (IC50: ethanol: 15.22±0.47 μg/mL) and BSA-methylglyoxal models (IC50: DCM : M: 278.29±8.55 μg/mL) were significantly high (p<0.05) in leaf.
Compared to the reference drugs used some of the biological activities were significantly (p<0.05) high (BEs: BChE inhibition and ethanol leaf: BSA-glucose mediated antiglycation), some were comparable (BEs: BSA-glucose mediated antiglycation), and some were moderate (BEs and LEs: antiamylase, AChE inhibition, and BSA-MGO mediated antiglycation; DCM : M leaf: BSA-glucose mediated antiglycation).
TP were significantly high (p<0.05) in BEs compared to LEs (BEs and LEs: 1097.90±73.01–1381.53±45.93 and 309.52±2.81–434.24±14.12 mg cyanidin equivalents/g extract, resp.).
In conclusion, both bark and leaf of CC possess antidiabetic properties and thus may be useful in managing diabetes and its complications.
American Psychological Association (APA)
Arachchige, Sirimal Premakumara Galbada& Abeysekera, Walimuni Prabhashini Kaushalya Mendis& Ratnasooriya, W. D.. 2017. Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153951
Modern Language Association (MLA)
Arachchige, Sirimal Premakumara Galbada…[et al.]. Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153951
American Medical Association (AMA)
Arachchige, Sirimal Premakumara Galbada& Abeysekera, Walimuni Prabhashini Kaushalya Mendis& Ratnasooriya, W. D.. Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153951