The Value of PD-L1 Expression in Predicting the Efficacy of Anti-PD-1 or Anti-PD-L1 Therapy in Patients with Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Yuan, Shu-Qiang
Chen, Xiao-Jiang
Duan, Jin-Ling
Chen, Yong-Ming
Chen, Shi
Wang, Yun
Li, Yuan-Fang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objectives.
Recent trials have shown an overall survival (OS) benefit in 10-40% advanced cancer patients treated with programmed cell death 1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitors.
Here, we aimed to evaluate the relationship between PD-L1 expression and the therapeutic efficacy of PD-1 or PD-L1 inhibitors in patients with cancer with recurrent or metastatic disease, compared with control treatments.
Methods.
We systematically searched Medline (PubMed), Embase, and Cochrane Library databases up to Jan 2019 and pooled the treatment effects (hazard ratio or relative ratio) of PD-1/PD-L1 inhibitors in patients with different PD-L1 expression.
Results.
Overall, twenty-four qualifying trials with over 14,860 subjects were eligible in this study.
Compared with conventional agents, anti-PD/PD-L1 drugs significantly reduced the risk of death (hazard ratio 0.72, 95% CI 0.66 to 0.78), irrespective of the tumor type.
Additionally, when PD-L1 expression ≥1% was defined as positive, anti-PD-1/PD-L1 monotherapy correlated with prolonged overall survival in patients with nonsmall cell lung cancer (NSCLC) (0.72, 0.61 to 0.86) and other cancer types (0.66, 0.57 to 0.76) patients with PD-L1 positive, rather than those with PD-L1 negative (hazard ratio for NSCLC and other cancer types: 0.84 and 0.87, respectively; all P>0.05).
The subgroup analyses to experimental agents, PD-1/PD-L1 inhibitors, PD-L1 antibody clone, and type of IHC scoring method validated the robustness of these findings.
However, anti-PD-1/PD-L1 combination therapies can reduce the risk of death for patients with different cancer types, regardless of PD-L1 expression (P<0.05 for all PD-L1 expression status).
Conclusions.
We recommend PD-L1 expression as a predictive biomarker in patient selection for anti-PD-1/PD-L1 monotherapy, but not for combination therapies.
American Psychological Association (APA)
Chen, Xiao-Jiang& Yuan, Shu-Qiang& Duan, Jin-Ling& Chen, Yong-Ming& Chen, Shi& Wang, Yun…[et al.]. 2020. The Value of PD-L1 Expression in Predicting the Efficacy of Anti-PD-1 or Anti-PD-L1 Therapy in Patients with Cancer: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1153968
Modern Language Association (MLA)
Chen, Xiao-Jiang…[et al.]. The Value of PD-L1 Expression in Predicting the Efficacy of Anti-PD-1 or Anti-PD-L1 Therapy in Patients with Cancer: A Systematic Review and Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1153968
American Medical Association (AMA)
Chen, Xiao-Jiang& Yuan, Shu-Qiang& Duan, Jin-Ling& Chen, Yong-Ming& Chen, Shi& Wang, Yun…[et al.]. The Value of PD-L1 Expression in Predicting the Efficacy of Anti-PD-1 or Anti-PD-L1 Therapy in Patients with Cancer: A Systematic Review and Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1153968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153968