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Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole-Kindled Mice
Joint Authors
Aldawsari, Hibah
Badr, Jihan M.
Eid, Basma G.
Neamatallah, Thikrayat
Zaitone, Sawsan A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Anticonvulsant and neuroprotective activity of Phragmanthera austroarabica extract were tested in pentylenetetrazole-kindled mice.
All the chemical constituents of the plant extract were identified.
Additionally, the extract was standardized and proved to contain total phenolic contents equal to 379.92±1.32 mg gallic acid equivalents/g dry plant extract.
Induction of kindling was achieved by repeated intraperitoneal administration of pentylenetetrazole (35 mg/kg) twice weekly.
Male albino mice were given P.
austroarabica extract (200, 400, or 800 mg/kg).
The two higher doses (400 or 800 mg/kg) of the extract significantly caused notable reduction in seizure activity and hippocampal malondialdehyde level compared to pentylenetetrazole control group.
The highest dose enhanced cortical GSH level and showed intact DNA in the laddering assay.
Upon studying the neuroprotective effect, mice treated with the higher dose of the extract demonstrated an improvement in the percent of surviving neurons in the cortex and hippocampus.
We concluded that P.
austroarabica extract ameliorated seizure activity and protected cortical and hippocampal neurons against pentylenetetrazole-induced kindling in mice.
American Psychological Association (APA)
Aldawsari, Hibah& Eid, Basma G.& Neamatallah, Thikrayat& Zaitone, Sawsan A.& Badr, Jihan M.. 2017. Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole-Kindled Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153973
Modern Language Association (MLA)
Aldawsari, Hibah…[et al.]. Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole-Kindled Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1153973
American Medical Association (AMA)
Aldawsari, Hibah& Eid, Basma G.& Neamatallah, Thikrayat& Zaitone, Sawsan A.& Badr, Jihan M.. Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole-Kindled Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1153973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153973