Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus
Joint Authors
Fu, Biqi
Luo, Qing
Guo, Yang
Huang, Zikun
Li, Junming
Zhang, Lu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although it has been proved that the epigenetic modification of DNA and histones is involved in the pathogenesis of systemic lupus erythematosus (SLE), there is no study to explore whether the modification of N6-methyladenosine (m6A) in RNA is involved.
In this study, the mRNA levels of m6A “writers” (METTL3, MTEEL14, and WTAP), “erasers” (FTO and ALKBH5), and “readers” (YTHDF2) in peripheral blood were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
The results demonstrated that the mRNA levels of METTL3, WTAP, FTO, ALKBH5, and YTHDF2 in peripheral blood from SLE patients were significantly decreased.
The levels of ALKBH5 mRNA in SLE patients were associated with anti-dsDNA, antinucleosome, rash, and ulceration.
Multivariate logistic regression analysis showed that the level of ALKBH5 mRNA in peripheral blood is a risk factor of SLE (P<0.001).
Moreover, our results suggested that there was a positive correlation between m6A“writers” (METTL3 and WTAP), “erasers” (FTO and ALKBH5), and “readers” (YTHDF2) in SLE patients.
This study suggests that the mRNA level of ALKBH5 in peripheral blood may be involved in the pathogenesis of SLE.
American Psychological Association (APA)
Luo, Qing& Fu, Biqi& Zhang, Lu& Guo, Yang& Huang, Zikun& Li, Junming. 2020. Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154023
Modern Language Association (MLA)
Luo, Qing…[et al.]. Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1154023
American Medical Association (AMA)
Luo, Qing& Fu, Biqi& Zhang, Lu& Guo, Yang& Huang, Zikun& Li, Junming. Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154023