Genome-Wide Profiling Reveals That Herbal Medicine Jinfukang-Induced Polyadenylation Alteration Is Involved in Anti-Lung Cancer Activity
Joint Authors
Lu, Jun
Wu, Jun
Zhao, Xiaodong
Kou, Yao
Li, Guoqing
Shao, Jinhui
Liu, Cong
Tian, Jing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alternative polyadenylation (APA) plays an important role in regulation of genes expression and is involved in many biological processes.
As eukaryotic cells receive a variety of external signals, genes produce diverse transcriptional isoforms and exhibit different translation efficiency.
The traditional Chinese medicine (TCM) Jinfukang (JFK) has been effectively used for lung cancer treatment.
In this study, we investigated whether JFK exerts its antitumor effect by modulating APA patterns in lung cancer cells.
We performed a genome-wide APA site profiling analysis in JFK treated lung cancer cells A549 with 3T-seq approach that we reported previously.
Comparing with those in untreated A549, in JFK treated A549 we observed APA-mediated 3′ UTRs alterations in 310 genes including 77 genes with shortened 3′ UTRs.
In particular, we identified TMEM123, a gene involved in oncotic cell death, which produced transcripts with shortened 3′ UTR and thus was upregulated upon JFK treatment.
Taken together, our studies suggest that APA might be one of the antitumor mechanisms of JFK and provide a new insight for the understanding of TCM against cancer.
American Psychological Association (APA)
Kou, Yao& Li, Guoqing& Shao, Jinhui& Liu, Cong& Wu, Jun& Lu, Jun…[et al.]. 2017. Genome-Wide Profiling Reveals That Herbal Medicine Jinfukang-Induced Polyadenylation Alteration Is Involved in Anti-Lung Cancer Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154040
Modern Language Association (MLA)
Kou, Yao…[et al.]. Genome-Wide Profiling Reveals That Herbal Medicine Jinfukang-Induced Polyadenylation Alteration Is Involved in Anti-Lung Cancer Activity. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154040
American Medical Association (AMA)
Kou, Yao& Li, Guoqing& Shao, Jinhui& Liu, Cong& Wu, Jun& Lu, Jun…[et al.]. Genome-Wide Profiling Reveals That Herbal Medicine Jinfukang-Induced Polyadenylation Alteration Is Involved in Anti-Lung Cancer Activity. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154040